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Uveitis and blindness in a closed herd of Equidae following leptospiral infection.
Front Vet Sci
January 2025
Department of Clinical Sciences, North Carolina State University, Raleigh, NC, United States.
Objective: To describe the ocular findings, chronology of disease, and serum leptospiral titers in a group of horses, mules, and donkeys following an outbreak of leptospirosis.
Methods: Fifty Equidae in central North Carolina had ophthalmic examinations and serum leptospiral microscopic agglutination test (MAT) titers performed every 3-6 months for 24 months followed by a final examination at 34 months.
Results: Throughout the nearly three-year study period, 17 horses (34%; 17/49 horses) developed signs of uveitis; 20 eyes (20/34; 58.
In silico prediction and experimental evaluation of LIP3228 of pathogenic Leptospira as a potential subunit vaccine target against leptospirosis.
Biochem Biophys Res Commun
January 2025
Chula Vaccine Research Center (Chula VRC), Center of Excellence in Vaccine Research and Development, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand; Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand. Electronic address:
A protein subunit vaccine comprising conserved surface-exposed outer membrane proteins (SE-OMPs) is considered a promising platform for leptospirosis vaccine. The search for novel vaccine candidates that confer high protective efficacy against leptospirosis is ongoing. The LIP3228 protein was previously identified as a conserved and abundant SE-OMP with the potential to serve as an effective vaccine candidate.
View Article and Find Full Text PDFImmunological characterization of recombinant outer membrane Loa22 protein of local pathogenic serovars.
Vet Res Forum
October 2024
Department of Immunology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Leptospirosis is a worldwide zoonotic disease caused by pathogenic spp, often occurring in tropical and subtropical regions. Focusing on development of rapid diagnostic methods to facilitate early diagnosis and a universal vaccine are the main critical issues to overcome the burden of leptospirosis. Here, we have studied the immunogenic potential of prepared recombinant Loa22 protein (rLoa22) of local pathogenic species in mice and its ability to induce humoral and cellular immunity, being further evaluated by analyzing the immunoglobulin G (IgG) subclasses and cytokines produced through immunization.
View Article and Find Full Text PDFDiagnostic Pathways of spp. in Dogs with Kidney Injury.
Pathogens
September 2024
Horia Cernescu Research Unit, Faculty of Veterinary Medicine, University of Life Sciences "Regele Mihai I", 300645 Timisoara, Romania.
Article Synopsis
- Pathogenic species of Leptospira cause leptospirosis, leading to serious infections in both animals and humans, particularly affecting major organs.
- This study analyzed kidney injury and conducted a retrospective review from dog samples at the Faculty of Veterinary Medicine in Timisoara over several years, focusing on correlation with factors like breed, gender, and infection status.
- Findings revealed a significant link between unvaccinated dogs and increased leptospirosis risk, and compared diagnostic methods, showing that qPCR was more effective and specific for detecting leptospirosis than traditional immunohistochemistry (IHC).
Immune Cells and Infectious Diseases in Preeclampsia Susceptibility.
Can J Cardiol
December 2024
Cardiovascular Health Across the Lifespan Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada; School of Physical and Occupational Therapy, Faculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada. Electronic address:
Article Synopsis
- Preeclampsia is a serious pregnancy disorder affecting about 10% of pregnancies globally, characterized by high blood pressure and protein in the urine after 20 weeks, which poses risks to both mothers and babies.
- The condition's rising incidence is linked to factors like older maternal age and existing cardiovascular issues, with emerging ties to autoimmune and infectious diseases that can affect placental health.
- The review underscores the importance of understanding the immune mechanisms involved in preeclampsia, advocating for better diagnosis and monitoring of related diseases during pregnancy to improve health outcomes for mothers and infants.
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