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Severe oral mucositis is a major cause of a low quality of life in patients; however, the therapeutic effect of traditional treatments is insufficient. Therefore, we designed a carbopol gel based on rebamipide nanocrystals (REB NCs) and gum arabic (GA-REB@NP), and investigated its efficacy in accelerating wound healing in a hamster model of oral mucositis. REB NCs were prepared by bead milling, and GA- REB@NP were prepared by incorporating REB NCs into a carbopol gel.
View Article and Find Full Text PDFNondrug Intervention for Opportunistic Infections in Individuals With Hematological Malignancy: Systematic Review.
Interact J Med Res
March 2023
School of Medicine, Faculty of Health & Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
Background: Hematological malignancies disturb the blood, lymph nodes, and bone marrow. Taking medications for treating opportunistic infections (OIs) in these individuals may enhance the risk of medication interaction as well as adverse drug reactions.
Objective: This review aims to evaluate the effectiveness of nondrug interventions in reducing OIs among patients with hematological cancers.
Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms.
Front Cell Infect Microbiol
February 2023
Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff, United Kingdom.
Background: The increasing prevalence of invasive fungal infections in immuno-compromised patients is a considerable cause of morbidity and mortality. With the rapid emergence of antifungal resistance and an inadequate pipeline of new therapies, novel treatment strategies are now urgently required.
Methods: The antifungal activity of the alginate oligosaccharide OligoG in conjunction with nystatin was tested against a range of spp.
The prevalence, risk factors and antifungal sensitivity pattern of oral candidiasis in HIV/AIDS patients in Kumba District Hospital, South West Region, Cameroon.
Pan Afr Med J
December 2020
Office of the Dean, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Introduction: Oral candidiasis is one of the most common opportunistic infection in HIV/AIDS patient and it is caused by species. The low absolute CD4+T-lymphocyte count has traditionally been cited as the greatest risk factor for the development of Oral Candidiasis. The aim of this study was to identify species isolated from the oral cavity of HIV/AIDS patients, to determine their in vitro antifungal susceptibility and to investigate the possible risk factors associated with oral candidiasis.
View Article and Find Full Text PDFCurrent Trends in the Use of Two Combination Antifungal/Corticosteroid Creams.
J Pediatr
July 2017
Department of Dermatology, Pediatric Medical Office Building, Johns Hopkins Hospital, Baltimore, MD.
Superficial fungal infections are among the most commonly managed skin problems by general practitioners. Although evidence shows combination antifungal/corticosteroid topicals are more expensive and less effective than single-agent antifungals, practitioners continue to prescribe combination agents. We examined current prescription trends of 2 combination antifungal/corticosteroid medications, Lotrisone and Mycolog-II.
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