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A Gas Chromatography-Mass Spectrometry Method to Determine Tramadol Abuse Using Urine Samples.
Cureus
December 2024
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, IND.
Background The synthetic opioid tramadol is widely used as a pain reliever. Unlike other opioids, it is used freely worldwide, unaffected by international controls resulting in abuse and accidental intoxication. Analytical methods are necessary to prove tramadol abuse because 30% of the drug is excreted unchanged.
View Article and Find Full Text PDFUnique Research for Developing a Full Factorial Design Evaluated Liquid Chromatography Technique for Estimating Budesonide and Formoterol Fumarate Dihydrate in the Presence of Specified and Degradation Impurities in Dry Powder Inhalation.
Biomed Chromatogr
February 2025
Department of Chemistry, GITAM School of Science, GITAM Deemed to Be University, Hyderabad, India.
A simple LC method has been developed and validated for estimating budesonide (epimer B + A) and formoterol fumarate dihydrate in dry powder inhalation. The development results of this study make it very significant. The degradation and process impurities in EP and ChP were identified in addition to budesonide and formoterol fumarate.
View Article and Find Full Text PDFEco-sustainable chromatographic method for the determination of favipiravir and nitazoxanide for COVID-19: application to human plasma.
BMC Chem
January 2025
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nile Valley University (NVU), El Fayoum, 63518, Egypt.
Coronavirus disease 2019 (COVID-19), an extremely contagious illness, has posed enormous challenges to healthcare systems around the world. Although the evidence on COVID-19 management is growing, antiviral medication is still the first line of treatment. Therefore, it is critical that effective, safe, and tolerable antivirals be available to treat early COVID-19 and stop its progression.
View Article and Find Full Text PDFExploratory multivariate analysis using R Language for method development in liquid chromatography.
Anal Bioanal Chem
January 2025
Department of Medical Biochemistry, Faculty of Medicine in Hradec Králové, Charles University, Šimkova 870, 500 03, Hradec Králové, Czech Republic.
The visual evaluation of data derived from screening and optimization experiments in the development of new analytical methods poses a considerable time investment and introduces the risk of subjectivity. This study presents a novel approach to processing such data, based on factor analysis of mixed data and hierarchical clustering - multivariate techniques implemented in the R programming language. The methodology is demonstrated in the early-stage screening and optimization of the chromatographic separation of 15 structurally diverse drugs that affect the central nervous system, using a custom R Language script.
View Article and Find Full Text PDFFeasible band boundaries computation in bilinear matrix decomposition using essential data.
Anal Chim Acta
January 2025
, Institute for Advanced Studies in Basic Sciences, 45195-1159, Zanjan, Iran. Electronic address:
Background: Multivariate curve resolution methods are usually confronted with non-unique pure component factors. This rotational ambiguity can be represented by ranges of feasible profiles, which are equally compatible with the imposed constraints. Sensor-wise N-BANDS is an effective algorithm for the calculation of the bounds of feasible profiles in the presence of noise, but suffers from high computational cost.
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