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The Maturation of the International Health Crisis Response: The Polish Typhus Epidemic of 1916-1923 Compared to the African Ebola Virus Disease Epidemic of 2013-2016: Part I, the Polish Epidemic.
Epidemiologia (Basel)
December 2024
Division of Infectious Diseases, Medical Service, South Texas Veterans Healthcare System, 7400 Merton Minter Blvd, San Antonio, TX 78229, USA.
Poland suffered an epidemic of louse-borne typhus from 1916-1923, with 400,000 cases and more than 130,000 deaths. The causative factors were depressed economic conditions and a refugee crisis that engulfed Poland after World War I. The recognition of the epidemic in 1919 stimulated the creation of the League of Red Cross Societies (LRCS).
View Article and Find Full Text PDFInhibitors of Rickettsia prowazekii methionine aminopeptidase 1 identified from the Pandemic Response Box.
Bioorg Med Chem Lett
November 2024
Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115, United States. Electronic address:
Methionine aminopeptidase (MetAp) enzymes catalyze the post-translational removal of the initiator methionine residue in newly synthesized proteins, a process that is often essential in the maturation of proteins. Consequently, these enzymes serve as important targets for drug development. Rickettsia prowazekii (Rp) is an obligate coccobacillus and the causative agent of the louse-borne epidemic typhus and despite adequate treatment causes a latent infection.
View Article and Find Full Text PDFRudolph Virchow's Upper Silesia report: the starting point for his simultaneous engagement with public health and antisemitism.
Pathologica
June 2024
Anatomic Pathology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
Article Synopsis
- In 2023, people remembered an important report by Virchow about a bad sickness called epidemic typhus that affected many Polish peasants.
- This report was also the beginning of Virchow's fight against unfair treatment of Jewish people, known as antisemitism.
- Today, there are still problems with antisemitism, especially after a tragic event on October 7, reminding us of the past and how we need to stand against hate.
Human rickettsial infections in India - A review.
J Vector Borne Dis
January 2024
Block Technology Manager, Department of Agriculture, Government of Puducherry, Karaikal, Puducherry, India.
Rickettsial infections are emerging and/or re-emerging disease that poses a serious global threat to humans and animals. Transmission to humans and animals is through the bite of the ectoparasites including ticks, fleas and chigger mites. Most of the rickettsial diseases are endemic in India, but underdiagnosed.
View Article and Find Full Text PDFRelapsing epidemic typhus (Brill-Zinsser disease) in China.
J Infect
May 2024
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, 102206 Beijing, China. Electronic address:
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