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Reusable gallium-based electrochemical sensor for efficient glucose detection.
Biosens Bioelectron
January 2025
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China; A Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing, 100191, China. Electronic address:
Among wearable sensing devices, electrochemical sensors are overwhelming in biochemical detection due to their simple design but high sensitivity. Most electrochemical sensors are disposable, which significantly impairs the service life. Here we present a reusable gallium (Ga)-based multilayer electrochemical glucose biosensor to extend noninvasive monitoring of glucose in the interstitial fluid.
View Article and Find Full Text PDFApplication of PLGA-PEG-PLGA Nanoparticles to Percutaneous Immunotherapy for Food Allergy.
Molecules
August 2024
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda 278-8510, Chiba, Japan.
Compared with oral or injection administration, percutaneous immunotherapy presents a promising treatment modality for food allergies, providing low invasiveness and safety. This study investigated the efficacy of percutaneous immunotherapy using hen egg lysozyme (HEL)-loaded PLGA-PEG-PLGA nanoparticles (NPs), as an antigen model protein derived from egg white, compared with that of HEL-loaded chitosan hydroxypropyltrimonium chloride (CS)-modified PLGA NPs used in previous research. The intradermal retention of HEL in excised mouse skin was measured using Franz cells, which revealed a 2.
View Article and Find Full Text PDFEnhancing linezolid activity in the treatment of oral biofilms using novel chitosan microneedles with iontophoretic control.
Biomater Adv
November 2024
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, United Kingdom. Electronic address:
This study aimed to prepare and assess active microneedle (MN) patches based on a novel biomaterial and their effective coupled (physical and electrical) transdermal delivery of a model drug (Linezoid). Modified MN patches (e.g.
View Article and Find Full Text PDFAn update on the latest strategies in retinal drug delivery.
Expert Opin Drug Deliv
May 2024
Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE.
Introduction: Retinal drug delivery has witnessed significant advancements in recent years, mainly driven by the prevalence of retinal diseases and the need for more efficient and patient-friendly treatment strategies.
Areas Covered: Advancements in nanotechnology have introduced novel drug delivery platforms to improve bioavailability and provide controlled/targeted delivery to specific retinal layers. This review highlights various treatment options for retinal diseases.
Bilaterally Aligned Electroosmotic Flow Generated by Porous Microneedle Device for Dual-Mode Delivery.
Adv Healthc Mater
September 2024
Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-1 Aramaki Aoba, Aoba-ku, Sendai, 980-8579, Japan.
Here, a novel porous microneedle (PMN) device with bilaterally aligned electroosmotic flow (EOF) enabling controllable dual-mode delivery of molecules is developed. The PMNs placed at anode and cathode compartments are modified with anionic poly-2-acrylamido-2-methyl-1-propanesulfonic acid and cationic poly-(3-acrylamidopropyl) trimethylammonium, respectively. The direction of EOF generated by PMN at the cathode compartment is, therefore, reversed from cathode to anode, countering the unwanted cathodal suctioning of interstitial fluid caused by reverse iontophoresis.
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