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Aberrant acetylation caused by a CDYL splicing mutation contributes to thin mid-piece related asthenoteratozoospermia and male infertility.
Andrology
January 2025
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Objectives: Acetylated tubulin is a hallmark of flagellar stability in spermatozoa, and studies have demonstrated the ability of CDYL to function as a tubulin acetyltransferase in spermatozoa. Of note, germline conditional knockout of Cdyl can lead to asthenoteratozoospermia and infertility in male mice. However, the role of CDYL gene in human fertility remains uncharacterized.
View Article and Find Full Text PDFPsychological safety, Job satisfaction, and the Intention to Leave among German early-career physicians.
Int J Qual Health Care
January 2025
Institute for Patient Safety, University Hospital Bonn, Bonn, Germany.
Background: Healthcare systems worldwide experience shortages of healthcare professionals. Retention of physicians is becoming an increasing problem. The psychological safety among physicians affects not only performance, but also their emotional well-being and job satisfaction.
View Article and Find Full Text PDFAnalysis of the growth trajectories of junior residents in Japan: a longitudinal cohort study using data from a nationwide e-portfolio system (EPOC2).
BMJ Open
January 2025
Department of Medical Education Research and Development, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.
Objectives: As more emphasis is placed on the acquisition of competencies in medical education, portfolios are increasingly being used for evaluation. EPOC2 (E-POrtfolio of Clinical training) is an e-portfolio system developed in Japan and is used by about 800 clinical training hospitals. The study objective is to identify the learning trajectory of junior residents to provide insights into the provision of better postgraduate and undergraduate medical education in Japan.
View Article and Find Full Text PDFRabies-preventive health program for mothers in maternal and child health centers: quasi experimental study.
J Health Popul Nutr
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Community Health Nursing Department, Faculty of Nursing, Cairo University, Cairo, 11562, Egypt.
Background: Rabies spreads to people and animals via saliva, usually through bites, scratches, or direct contact with mucosa (e.g. eyes, mouth, or open wounds).
View Article and Find Full Text PDFPsychogenic hearing loss in children and adolescents. Diagnosis and psychotherapy.
Ann Med
December 2025
Department of Pediatric Otolaryngology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Introduction: Psychogenic hearing loss is often neglected in the differential diagnosis of hearing disorders. In a difficult diagnostic process and treatment of psychogenic hearing loss disorder, the close cooperation of the audiologist, psychologist, patient, and his family is required. The study aimed to improve the knowledge and understanding of psychogenic hearing loss, establish a differential diagnosis in audiological tests in children, determine diagnostic procedures and finally apply adequate therapeutic procedures.
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