By indirect immunofluorescence using antigens of hantavirus Hantaan and CG 18-20 on Vero E6 cells were examined 5,827 samples of sera from 5,299 probands of Czechoslovakia. In 49 persons (0.94%) were found antibodies of titres 1:32 and higher. Two groups of elderly farm workers showed a cluster of positive individuals amounting to 9.9% and 29.4% respectively. The ratio of positivities in some other, randomly and specifically selected groups was deep below 1%. The partial results for the group of farmers were confirmed by RIA test. Occasionally antibodies only to one of the hantavirus serotypes, at other time, to both were found. The authors discuss the findings of antibodies of the two serotypes in humans as related to the evidenced existence of two hantavirus antigen serotypes in animals.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source.
mBio
October 2024
Virology Division, USA Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland, USA.
Article Synopsis
- * SAB-163 is a new therapeutic treatment developed from transchromosomic bovine plasma, showing strong effectiveness against multiple hantavirus strains and extended bioavailability in animal models.
- * The treatment has demonstrated protective effects in hamsters when administered around the time of exposure and is now ready for phase 1 clinical trials after passing safety and efficacy tests.
Single-Domain Antibody-Gold Nanoparticle Bioconjugates as Immunosensors for the Detection of Hantaviruses.
Mol Diagn Ther
July 2024
Fundação Oswaldo Cruz, FIOCRUZ, Fiocruz Ceará, Eusébio, CE, Brazil.
Introduction: Hantavirus, a zoonotic pathogen, causes severe syndromes like hemorrhagic fever with renal syndrome (HFRS), sometimes fatal in humans. Considering the importance of detecting the hantavirus antigen, the construction of an immunosensor is essential. The structural and functional characteristics of camelid nanobodies (VHHs) encourage their application in the areas of nanobiotechnology, therapeutics, diagnostics, and basic research.
View Article and Find Full Text PDFHemorrhagic Fever with Renal Syndrome Complicated by Acute Pancreatitis, High Intraocular Pressure, and Pulmonary Involvement: a Case Report.
Infect Drug Resist
May 2024
Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130000, People's Republic of China.
Article Synopsis
- - Hemorrhagic fever with renal syndrome (HFRS) is a disease caused by hantaviruses, presenting symptoms like fever, hemorrhage, renal failure, and occasionally acute pancreatitis, highlighting the importance of recognizing diverse symptoms in affected patients.
- - A 30-year-old male with HFRS experienced fever, nausea, abdominal pain, petechiae, and elevated intraocular pressure, leading to a diagnosis that included acute pancreatitis confirmed by CT scans and a positive hantavirus antibody test.
- - The patient underwent treatment for both renal failure and respiratory complications, eventually recovering normal functions; this case emphasizes the necessity for thorough assessments and monitoring of HFRS patients, especially regarding intraocular pressure.
Background: Seoul virus (SEOV) is a significant causative pathogen of hemorrhagic fever with renal syndrome (HFRS). Accurate discrimination of SEOV infection from other viral or bacterial infections holds vital clinical importance.
Methods: Our study utilized quantitative real-time PCR (qRT-PCR), metagenomic next-generation sequencing (mNGS), and immunological assays to identify the pathogen causing HFRS.
Seroprevalence of Hantavirus among Manual Cane Cutters and Epidemiological Aspects of HPS in Central Brazil.
Viruses
November 2023
Hantaviruses and Rickettsiosis Laboratory, Oswaldo Cruz Institute (FIOCRUZ), Rio de Janeiro 21040-360, Brazil.
Hantavirus pulmonary syndrome (HPS) is a rodent-borne zoonotic disease that is endemic throughout the Americas. Agricultural activities increase exposure to wild rodents, especially for sugarcane cutters. We carried out a survey of the epidemiological aspects of HPS and investigated the prevalence of hantavirus infection in the sugarcane cutter population from different localities in the Brazilian Midwest region.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!