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Persistent Knee Monoarthritis as a Lyme Disease Presentation: A Diagnostic Challenge - Case Report.
Rev Bras Ortop (Sao Paulo)
November 2024
Hospital Ortopédico de Sant'Ana, Parede, Portugal.
There are several differential diagnoses for knee monoarthritis. We report a patient with recurrent episodes of knee effusion, in which the non-specific clinical condition implied several diagnostic hypotheses, therapeutic inaccuracies, and a delay in implementing adequate treatment. For more than 2 years, the patient underwent different Orthopedics and Rheumatology visits.
View Article and Find Full Text PDFDetermining the Efficacy of Chemicals for the Inactivation of Liquid Waste Containing Gram-Positive Bacteria of Risk Group 2.
Appl Biosaf
December 2024
Neuroinfection Laboratory Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Background: Inactivation of infectious liquid waste can be performed by different means, including autoclaving or chemical inactivation. Autoclaving is most widely used, but cannot always be implemented, so that chemical inactivation is a possible alternative. However, its efficacy has to be proven by in-house validation.
View Article and Find Full Text PDFDevelopment of high-performance inducible and secretory expression vector and host system for enhanced recombinant protein production.
Sci Rep
December 2024
Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi state, MS, 39762, USA.
The production of lipopolysaccharide (LPS)-free recombinant proteins from culture supernatants is of great interest to biomedical research and industry. Due to the LPS-free cell wall structure and the well-defined secretion factor B (SecB)-dependent secretion pathway, Gram-positive bacteria are a superior alternative to Escherichia coli expression systems. However, the lack of inducible expression systems for high yields has been a bottleneck.
View Article and Find Full Text PDFSynthesis of novel spiroisoxazolidino hybrids of alantolactone and isoalantolactone via 1,3 dipolar nitrone cycloaddition and its antimicrobial Evaluation.
Bioorg Chem
December 2024
CSIR- Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Alantolactone and isoalantolactone are two isomeric sesquiterpene lactones that were isolated from Innula recemosa. Here, we are used for the semisynthesis of novel isoxazolidine hybrids of alantolactone and isoalantolactone through a two-step process: nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The formation of the cycloadduct was well characterized via modern spectroscopic techniques such as HRMS, H NMR, C NMR, DEPT-90, DEPT-135, and 2D NMR.
View Article and Find Full Text PDFMicrobial Spectrum, Intraoperative Findings, and Postoperative Outcomes in Native Knee Joint Infections: A Retrospective Analysis.
Clin Pract
December 2024
Department of Orthopedics and Trauma Surgery, University Hospital of Bonn, 53127 Bonn, Germany.
Native knee joint infections, while uncommon, present a serious condition predominantly instigated by bacteria such as . Without timely intervention, they can result in joint destruction or sepsis, with risk factors encompassing preexisting medical conditions and iatrogenic procedures. The diagnostic process includes a comprehensive patient history, clinical evaluation, laboratory testing, imaging studies, and microbiological investigations.
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