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Synthesizing Genotoxicity Results in the MultiFlow Assay With Point-of-Departure Analysis and ToxPi Visualization Techniques.
Environ Mol Mutagen
March 2025
Instiutue of Life Sciences, Swansea University, Swansea, UK.
In vitro genotoxicity has historically served a hazard identification role, with simple binary outcomes provided for each of several single endpoint assays. This will need to change, given: (i) efforts to curtail animal testing, (ii) the increased use of multiplexed in vitro assays and the ongoing development of NAMS, and (iii) the desire to holistically consider quantitative results from multiple biomarkers/endpoints that take potency into consideration. To help facilitate more quantitative analyses of multiple biomarkers and/or assay streams, we explored the combined use of PROAST and Toxicological Prioritization Index (ToxPi) software.
View Article and Find Full Text PDFCatalytic Production of Aromatic Amines From Nitroaromatics - Adressing a Critical Challenge in Environmental Remediation.
Chemistry
March 2025
Wrocław University of Science and Technology, Department of Process Engineering and Technology of Polymer and Carbon Materials, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, POLAND.
The present work reviews the continuous flow hydrogenation of nitroaromatic compounds (NACs) to aromatic amines, highlighting its significance in sustainable chemical manufacturing. These processes offer enhanced efficiency, scalability, and safety compared to traditional batch methods, addressing the environmental concerns associated with NAC contamination. In this context, the flow mode processes of NACs hydrogenation may be considered as tools for catalytically-driven extraction of fine chemical products.
View Article and Find Full Text PDFEffects of composition on the explosive properties of potassium chlorate and oils.
Forensic Sci Res
March 2025
Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic.
Unlabelled: Potassium chlorate has long been utilized as an excellent oxidizing agent in pyrotechnics and explosives. As mixtures of potassium chlorate and any type of combustible material can be explosive, there is a potential risk of misuse in homemade explosives. Unlike commercial explosives, homemade chlorate and oil mixtures do not have a constant composition, which limits their understanding.
View Article and Find Full Text PDFGeopolymer-Based Stabilization of Heavy Metals, the Role of Chemical Agents in Encapsulation and Adsorption: Review.
Polymers (Basel)
March 2025
Department of Engineering 'Enzo Ferrari', University of Modena and Reggio Emilia, Via Vivarelli 10, 41125 Modena, Italy.
This review provides a comprehensive analysis of the role of chemical agents in enhancing the performance of geopolymers for the stabilization and adsorption of heavy metals. Geopolymers, synthesized from aluminosilicate sources activated under alkaline conditions, are recognized for their versatile structural and environmental benefits, including low carbon emissions and high chemical resistance. Their unique Si-O-Al framework supports both stabilization/solidification (S/S) and adsorption processes, making them an ideal polymeric matrix for the immobilization of hazardous heavy metals in contaminated environments.
View Article and Find Full Text PDFFirst-Line Tislelizumab Plus Chemotherapy for Advanced Gastric Cancer with Programmed Death-Ligand 1 Expression ≥ 1%: A Retrospective Analysis of RATIONALE-305.
Adv Ther
March 2025
Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dong Feng East Road, Guangzhou, 510060, People's Republic of China.
Introduction: Tislelizumab plus investigator-chosen chemotherapy (ICC) demonstrated a statistically significant improvement in overall survival (OS) versus placebo plus ICC in RATIONALE-305 in patients with locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric cancer/gastroesophageal junction cancer (GC/GEJC) in the intent-to-treat population and in patients with programmed death-ligand 1 (PD-L1) Tumor Area Positivity (TAP) score ≥ 5%. The United States Food and Drug Administration Oncologic Drugs Advisory Committee voted (September 2024) against first-line treatment with programmed cell death protein-1 inhibitors in this setting in patients with a PD-L1 combined positive score < 1 or TAP score < 1%, due to an unfavorable benefit-risk profile. Thus, we retrospectively analyzed data from RATIONALE-305 in patients with a PD-L1 TAP score ≥ 1%.
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