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Developing a Label-Free Infrared Spectroscopic Analysis with Chemometrics and Computational Enhancement for Assessing Lupus Nephritis Activity.
Biosensors (Basel)
January 2025
National Synchrotron Radiation Research Center, Hsinchu 300092, Taiwan.
Patterns of disease and therapeutic responses vary widely among patients with autoimmune glomerulonephritis. This study introduces groundbreaking personalized infrared (IR)-based diagnostics for real-time monitoring of disease status and treatment responses in lupus nephritis (LN). We have established a relative absorption difference (RAD) equation to assess characteristic spectral indices based on the temporal peak heights (PHs) of two characteristic serum absorption bands: ν as the target signal and ν as the PH reference for the ν absorption band, measured at each dehydration time (t) during dehydration.
View Article and Find Full Text PDFA Case of Radiation Nephropathy Complicated by Tubulointerstitial Nephritis with Predominantly Lymphocyte and Plasma Cell Infiltration.
Intern Med
November 2024
Departments of Nephrology, National Hospital Organization Kyoto Medical Center, Japan.
Article Synopsis
- A 64-year-old Japanese woman diagnosed with stage IVB cervical cancer experienced gross hematuria and renal dysfunction after chemoradiation therapy.
- A renal biopsy indicated rare complications: renal thrombotic microangiopathy (TMA) and tubulointerstitial nephritis (TIN), which are unusual for radiation nephropathy.
- The use of contrast-enhanced CT identified high radiation dose areas in the kidneys, demonstrating the need for a combined approach of clinical, pathological, and radiological assessments in diagnosing radiation nephropathy.
Immunoglobulin A-dominant membranoproliferative glomerulonephritis-like pattern of injury as a possible paraneoplastic nephropathy in a breast cancer patient.
CEN Case Rep
October 2024
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan.
Article Synopsis
- A middle-aged woman diagnosed with breast cancer developed worsening kidney issues, leading to nephrotic syndrome characterized by proteinuria and hematuria.
- After receiving hormone therapy for her cancer, a kidney biopsy showed signs of IgA nephropathy, ruled out other potential causes.
- Following breast cancer surgery and radiation, her kidney symptoms improved significantly, indicating a possible paraneoplastic glomerulopathy related to her breast cancer.
Quantitative evaluation of Ga-citrate scintigraphy in the management of nephritis.
Sci Rep
July 2024
Tokushima University Graduate School of Biomedical Sciences, Kuramoto-cho 3-18-15, Tokushima, Tokushima, 770-8503, Japan.
In Ga-citrate scintigraphy (Ga-S), visual assessment is used by evaluating renal-uptake comparison with liver and spine and is simple and objective. We adopted the standardized uptake value (SUV) for Ga-citrate and proposed two quantitative indices, active nephritis volume (ANV) and total nephritis uptake (TNU). This study clarified the utility of new Ga-S-based quantitative indices in nephritis management.
View Article and Find Full Text PDFCardiorenal Impact of Anti-Cancer Agents: The Intersection of Onco-Nephrology and Cardio-Oncology.
Cardiorenal Med
June 2024
Northwell Health, New York, New York, USA.
Background: The evolving landscape of cancer treatments has introduced new challenges, particularly related to adverse events associated with chemotherapeutic agents. To address these challenges, the fields of cardio-oncology and onco-nephrology have arisen, focusing on the management of cardiotoxicity and nephrotoxicity attributable to anti-cancer drugs.
Summary: Numerous intersections between these disciplines exist, including onco-hypertension (HTN) and cardiorenal toxicities induced by chemotherapeutic agents.
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