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Risk Assessment of Psychotropic Drugs on Mitochondrial Function Using In Vitro Assays.
Biomedicines
December 2023
Department of Pharmaceutical Sciences, Barry & Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Ft. Lauderdale, FL 33328-2018, USA.
Article Synopsis
- This study explores how 22 psychotropic drugs affect mitochondrial function, specifically looking at their potential to cause organ toxicity.
- Several drugs were found to inhibit the electron transport chain (ETC) or act as uncouplers, with varying levels of cytotoxicity identified in HepG2 cells and isolated rat liver mitochondria.
- The findings help clarify the molecular mechanisms behind drug-induced mitochondrial toxicity, which can inform safer clinical drug choices.
Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer.
Neurosci Biobehav Rev
October 2022
P.O. Box 622, Midlothian, VA 23113, United States. Electronic address:
Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine antipsychotic, chlorpromazine, was found to inhibit cancer. During the years of elucidating the pharmacology of the phenothiazines, reserpine, an antipsychotic with a long historical background, was likewise discovered to have anti-cancer properties.
View Article and Find Full Text PDFA Systematic Review of Various Screening Models as well as the Mechanisms Involved in Parkinson's Disease Screening Procedures.
Curr Rev Clin Exp Pharmacol
January 2024
Bharat Institute of Technology, School of Pharmacy, Meerut, Uttar Pradesh, India.
Background: Parkinson's disease is the second most common neurological ailment. It is also known that it affects practically all other brain components, although only gradually. Animal models are mostly used to test the efficacy of treatment against a specific enzyme and aid in creating a new drug dose.
View Article and Find Full Text PDFCREM, PRM I and II gene expression in Wistar rats testes treated with antipsychotic drugs: Chlorpromazine, Rauwolfia vomitoria and co-administration of reserpine, zinc and ascorbic acid.
JBRA Assist Reprod
February 2021
Department of Anatomy, University of Medical Sciences, Ondo City, Ondo State, Nigeria.
Objective: The literature has shown that synthetic antipsychotic drugs induce reproductive toxicity, while psychiatric patients treated with traditionally used antipsychotic herbs (Rauwolfia vomitoria) showed no traces of reproductive toxicity. Thus, this study aimed to investigate the expression of CREM, PRM I and II genes in the testes of Wistar rats treated with antipsychotic drugs: chlorpromazine, Rauwolfia vomitoria (RV) and co-administration of reserpine, zinc and ascorbate (RAZ).
Methods: Forty-five adult male Wistar rats with rats with average weight of 180±4.
Intestinal absorption mechanisms of araloside A in situ single-pass intestinal perfusion and in vitro Caco-2 cell model.
Biomed Pharmacother
October 2018
Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China. Electronic address:
Araloside A is a triterpenoid saponin,which exhibits a broad spectrum of pharmacological activities, such as stimulating fibrinolysis, preventing coagulant, inhibiting renin, and decreasing blood pressure. Our previous report found that the compound exhibits a poor absolute bioavailability. However the underlying mechanisms of its absorption have not been investigated in the small intestine or in a Caco-2 cell model.
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