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Novel approach to managing two enormous bezoars with successive snare-tip electrocautery: A case report.
World J Gastrointest Endosc
January 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Lukang Christian Hospital, Changhua 505002, Taiwan.
Background: Gastric bezoars are indigestible masses that can lead to gastrointestinal obstruction and ulceration. Standard treatments include endoscopic mechanical lithotripsy with a polypectomy snare and Coca-Cola dissolution therapy or a combination of both approaches. However, giant bezoars frequently require multiple treatment sessions and extended hospital stays.
View Article and Find Full Text PDFPhenylboronic Acid-Modified Carbon Dot-Proteinase K Nanohybrids for Enhanced Photodynamic Therapy Against Bacterial Biofilm Infections.
Acta Biomater
January 2025
Department of radiology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address:
Nanohybrids combining phenylboronic acid-modified carbon dots (PCDs) and proteinase K have been engineered for addressing the formidable challenges of antimicrobial photodynamic therapy (aPDT) against bacterial biofilm infections, overcoming biofilm barrier obstruction, the limited diffusion of reactive oxygen species (ROS), and the inadequate ROS generation of traditional photosensitizers. PCDs are formulated for superior water solubility and robust singlet oxygen (O) production, mitigating issues related to dispersion and aggregation-induced quenching typical of conventional photosensitizers. The conjugation of phenylboronic acid to CDs not only enhanced O generation through increased electron-hole separation but also imparted strong bacterial binding capabilities to the PCDs, enabling broad-spectrum sterilization by maximizing the ROS-mediated bacterial destruction.
View Article and Find Full Text PDFSynergistic SERS Enhancement of Highly Sensitive and Reusable rGO-Ag-ZrO Thin Film Nanocomposite to Detect Synthetic Textile Dyes.
Langmuir
January 2025
Centre for Nano and Soft Matter Sciences, Shivanapura, Dasanapura Hobli, Bangalore 562162, India.
The textile industry is one of the main industries that benefited from the industrial revolution. Therefore, discharging of dyes from textile, paper, plastic, and rubber industries is inevitable. This colored wastewater prevents sunlight penetration and highly affects water sources.
View Article and Find Full Text PDFMicroplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities.
Sci Adv
January 2025
State Key Laboratory of Environment Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China.
Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting the regular physiological processes of organs. Nanoscale plastics can breach the blood-brain barrier, leading to neurotoxic effects.
View Article and Find Full Text PDFAsperulosidic acid inhibits the PI3K/Akt/NF-κB pathway to suppress endotoxin-induced uveitis.
Front Med (Lausanne)
January 2025
Department of Ophthalmology, Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Introduction: Uveitis, a severe inflammatory disease affecting the uvea, is associated with visual impairment and irreversible blindness. Asperulosidic Acid (ASPA), derived from , is known for its notable anti-inflammatory and antioxidant characteristics.
Methods: The present study explored the potential anti-inflammatory effects and the fundamental processes of ASPA by injecting it or a placebo into the vitreous of rats with endotoxin-induced uveitis (EIU).
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