Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Cotadutide reversible self-assembly based long-acting injectable depot for sustained delivery of GLP-1 glucagon receptor agonists with controlled burst release.
J Control Release
January 2025
Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Waltham, MA, USA.
Cota is a lipidated dual GLP-1 and Glucagon receptor agonist that was investigated for the treatment of various metabolic diseases, it is designed for once daily subcutaneous administration. Invasive daily injections often result in poor patient compliance with chronic disease, and here, we demonstrate an innovative strategy of encapsulating reversible cota self-assembled fibers within an in-situ forming depot of low molecular weight poly(lactic-co-glycolic) acid (LWPLGA) for sustained delivery GLP-1 and Glucagon receptor agonist with controlled burst release. This could be a suitable alternative to other sustained delivery strategies for fibrillating peptides.
View Article and Find Full Text PDFAn in-situ forming controlled release soft hydrogel-based C5a peptidase drug delivery system to treat psoriasis.
Int J Pharm
January 2025
Department of Chemical Sciences, Bernal Institute, University of Limerick, Ireland; SSPC Science Foundation Ireland Research Centre for Pharmaceuticals, University of Limerick, Ireland. Electronic address:
The potent pro-inflammatory cytokine, interferon gamma (IFN-γ), is an enticing therapeutic target because of its accelerator role in several acute and chronic inflammatory processes. In this work, poloxamer 407 is developed as an in-situ gelling polymer for a long-acting formulation to deliver a serine protease, C5a peptidase (ScpA) from Streptococcus pyogenes. ScpA is well known for its activity against the complement factor C5a but has also recently been shown to cleave IFN-γ in vitro into inactive fragments.
View Article and Find Full Text PDFMassive Carbon Black Inhalation.
J Community Hosp Intern Med Perspect
January 2025
Departments of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Carbon black is the general term for a powdery commercial form of carbon. It can cause adverse health effects after inhalation, ingestion, or dermal contact. Exposure to carbon black particles can have adverse effects on the respiratory system; this exposure usually occurs when people inhale contaminated air in the workplace.
View Article and Find Full Text PDFThe temporal relationship between mitochondrial quality and renal tissue recovery following ischemia-reperfusion injury.
Heliyon
January 2025
School of Chemical and Biotechnology, SASTRA Deemed University, Tirumalaisamudram, Thanjavur, Tamil Nadu, India.
Background: Growing evidence indicates that disruptions in mitochondrial quality management contribute to the development of acute kidney injury (AKI), incomplete or maladaptive kidney repair, and chronic kidney disease. However, the temporal dynamics of mitochondrial quality control alterations in relation to renal injury and its recovery remain poorly understood and are addressed in this manuscript.
Method: ology: Male Wistar rats (n = 60) were subjected to varying durations of ischemia and reperfusion.
Achieving Near Infrared Photodegradation by the Synergistic Effect of Z-Scheme Heterojunction and Antenna of Rare Earth Single Atoms.
Small
January 2025
Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education School of Chemistry and Materials Science, Heilongjiang University, Harbin, 150080, P. R. China.
Near-infrared light response catalysts have received great attention in renewable solar energy conversion, energy production, and environmental purification. Here, near-infrared photodegradation is successfully achieved in rare earth single atom anchored NaYF@g-CN heterojunctions by the synergistic effect of Z-scheme heterojunction and antenna of rare earth single atoms. The UV-vis light emitted by Tm can not only be directly absorbed by g-CN to generate electron-hole pairs, realizing efficient energy transfer, but also be absorbed by NaYF substrate, and generating photo-generated electrons at its impurity level, transferring the active charge to the valence band of g-CN, forming a Z-scheme heterojunction and further improving the photocatalytic efficiency.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!