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Pharyngeal Complications Following Two-Jaw Surgery.
Cureus
December 2024
Section of Anesthesiology, Department of Diagnostics and General Care, Fukuoka Dental College, Fukuoka, JPN.
Objective: Two-jaw surgery corrects jaw deformities by adjusting occlusion and reshaping the jaw. This technique carries a high risk of pharyngolaryngeal injury due to frequent head and neck movements during intraoperative maneuvers and prolonged intubation, although the details remain unclear. This study explored the frequency and causes of postoperative pharyngeal complications following maxillary translocation.
View Article and Find Full Text PDFData on hydrodynamic flow and aspiration mechanisms in a patient-specific pharyngolaryngeal model with variable epiglottis angles.
Data Brief
February 2025
Department of Biomedical Engineering, University of Massachusetts, 1 University Ave., Lowell, MA 01854, USA.
This dataset comprises a comprehensive collection of videos and images illustrating the fluid dynamics of swallowing and aspiration in a patient-specific pharyngolaryngeal model with varying epiglottis angles. The data also includes the physical properties of the fluids used, comprising dynamic viscosity, surface tension, and contact angle. Videos under varying swallowing conditions were collected to investigate the mechanisms underlying aspiration.
View Article and Find Full Text PDFDirect activation of toll-like receptor 4 signaling in group 2 innate lymphoid cells contributes to inflammatory responses of allergic diseases.
iScience
November 2024
Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Group 2 innate lymphoid cells (ILC2s) are key players in type 2 immunity, but whether they can be directly activated by microbial ligands remain uncertain. In this study, we observed a positive correlation between blood endotoxin (LPS) levels and circulating ILC2s in allergic patients. , LPS robustly induced ILC2 proliferation and production of type 2 effector cytokines.
View Article and Find Full Text PDFRelationship between Quality of Life and Swallowing in Hypertensive Individuals with Obstructive Sleep Apnea.
Dysphagia
November 2024
Faculty of Medicine, Department of Internal Medicine, Post graduate Program in Internal Medicine, Federal University of Rio de Janeiro - UFRJ, Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 255, 9º andar, sala 9E11, Ilha do Fundão CEP, Rio de Janeiro, RJ, 21941-590, Brazil.
Introduction: Obstructive sleep apnea (OSA) is closely associated with resistant hypertension (RHTN). Individuals with OSA may have sensory and muscular alterations in pharyngolaryngeal structures, potentially resulting in oropharyngeal dysphagia.
Objective: One objective of this study was to assess and compare the quality of life (QoL) and swallowing ability of resistant hypertensive patients with and without OSA.
Nuclear PD-L1 compartmentalization suppresses tumorigenesis and overcomes immunocheckpoint therapy resistance in mice via histone macroH2A1.
J Clin Invest
November 2024
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Canonically PD-L1 functions as the inhibitory immune checkpoint on cell surface. Recent studies have observed PD-L1 expression in the nucleus of cancer cells. But the biological function of nuclear PD-L1 (nPD-L1) in tumor growth and antitumor immunity is unclear.
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