AI Article Synopsis
- The study examined how temperature affects the anesthetic potency of halothane, enflurane, and ethanol in water fleas (Daphnia magna).
- In cooler temperatures, the Daphnia showed less activity without anesthetics.
- As temperatures rose, the gaseous potency of all anesthetics decreased, while halothane and enflurane potency dropped in water, but ethanol potency increased.
- Enthalpy calculations indicate that these potency variations are likely due to specific interactions with targets in the animals rather than just solubility changes in lipid membranes.
Article Abstract
1. The effects of temperature on the anesthetic potencies of halothane, enflurane and ethanol have been studied in the water flea Daphnia magna. 2. In the absence of anaesthetics, decreasing temperature resulted in decreased activity by the daphnids. 3. Potencies in the gas phase decreased with increasing temperature for all of the anaesthetics, while aqueous potency decreased for halothane and enflurane but increased for ethanol. 4. Enthalpy calculations suggest that the observed potency changes for the inhalational anaesthetics cannot be accounted for in terms of changing solubility in lipid bilayers but most likely reflect more specific interactions with animal target sites.
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| http://dx.doi.org/10.1016/0742-8413(92)90193-b | DOI Listing |
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