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Effects of sulphur thermal water inhalations in long-COVID syndrome: Spa-centred, double-blinded, randomised case-control pilot study.
Clin Med (Lond)
November 2024
School of Thermal Medicine, Department of Clinical, Internal Medicine, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy; Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy. Electronic address:
Background: The long-COVID syndrome is characterised by a plethora of symptoms. Given its social and economic impact, many studies have stressed the urgency of proposing innovative strategies other than hospital settings. In this double-blinded, randomised, case-control trial, we investigate the effects of sulphur thermal water inhalations, rich in HS, compared to distilled water inhalations on symptoms, inflammatory markers and nasal microbiome in long-COVID patients.
View Article and Find Full Text PDFMechanisms that potentially contribute to the development of post-streptococcal glomerulonephritis.
Pathog Dis
February 2024
School of Science & Technology, University of New England, NSW, Australia.
Post-streptococcal glomerulonephritis (PSGN) is primarily associated with preceding group A streptococcal skin or throat infections, now mainly observed in economically disadvantaged communities. This condition significantly predisposes individuals to later-life chronic kidney disease and concurrent renal complications, with the elderly experiencing increased severity and less favourable outcomes. Streptococcal pyrogenic exotoxin B and nephritis-associated plasmin receptor are identified nephritogenic antigens (nephritogens).
View Article and Find Full Text PDFArticle Synopsis
- There is a growing need for bioreactors capable of producing immune cells, particularly those derived from human induced pluripotent stem cells (hiPSCs), for drug testing and cell therapy, yet this area is underexplored.
- A new xeno-free bioreactor platform has been developed to continuously generate standardized macrophages from hiPSC-derived hematopoietic organoids, enabling weekly harvesting of these immune cells over multiple weeks.
- The resulting macrophages show consistent functionality, purity, and the ability to mimic developmental stages, making them suitable for use in immunomodulatory drug testing, without requiring further maturation steps.
Nano(bio)Materials Do Not Affect Macrophage Phenotype-A Study Conducted by the REFINE Project.
Int J Mol Sci
May 2024
Immunocompatibility Group, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L7 3NY, UK.
Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate primary cell responses, particularly those of human cells. Isolation of tissue-resident macrophages from humans is difficult and may result in insufficient cells with which to determine the possible interaction with nano(bio)materials.
View Article and Find Full Text PDFA comprehensive bench-to-bed look into the application of gamma-sterilized 3D-printed polycaprolactone/hydroxyapatite implants for craniomaxillofacial defects, an in vitro, in vivo, and clinical study.
Biomater Adv
July 2024
Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Craniofacial and Cleft Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
This study investigates the safety and efficacy of 3D-printed polycaprolactone/hydroxyapatite (PCL/HA) scaffolds for patient-specific cranioplasty surgeries, employing liquid deposition modeling (LDM) technology. This research is pioneering as it explores the impact of gamma radiation on PCL/HA scaffolds and utilizes printing ink with the highest content of HA known in the composite. The mechanical, morphological, and macromolecular stability of the gamma-sterilized scaffolds were verified before implantation.
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