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The medical treatment of Parkinson disease from James Parkinson to George Cotzias.
Mov Disord
January 2015
Columbia University College of Physicians and Surgeons, New York, New York, USA.
It took exactly 150 years since James Parkinson's description in 1817 of the illness bearing his name until the development of effective therapy for this disorder, namely, the introduction of high-dosage levodopa by George Cotzias in 1967. During the first 50 years, no effective therapy was available, but neurologists reported using different agents, including metals. Then, around 1867, Charcot found solanaceous alkaloids to be somewhat helpful, and these became the accepted and popular therapy for the next 75 years.
View Article and Find Full Text PDFThe essay below, published in the Dr. Whatsisname column in the June 1959 issue of Mental Hospitals, takes a wry look at the wholesale discharge of patients from mental hospitals following the introduction of the new drugs. (See "The New Drugs (Chlorpromazine & Reserpine): Administrative Aspects" on page 327 and Dr.
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