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Evaluation of the merit of ethanolic extract of as an anti-cancer agent in human colon cancer cell lines (HCT-116).
F1000Res
January 2025
Department of Biochemistry, Kastubra Medical College Manipal, Maniapl Academy of Higher Education, Manipal, Karnataka, India.
Background: Colon cancer is the third most common cancer type worldwide. Novel alternative therapeutic anti-cancer drugs against colon cancer with less toxicity are to be explored . This study was aimed to explore the anti-proliferative and anti-migratory activity of various fractions of ethanolic leaf extract on human colon cancer cell lines (HCT-116) and to explore the potential molecular targets from the most potent plant extract fraction.
View Article and Find Full Text PDFMetabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya.
BMC Genomics
January 2025
Program in Public Health, College of Health Sciences, University of California, Irvine, California, USA.
Background: The resurgence of Anopheles funestus, a dominant vector of human malaria in western Kenya was partly attributed to insecticide resistance. However, evidence on the molecular basis of pyrethroid resistance in western Kenya is limited. Here, we reported metabolic resistance mechanisms and demonstrated that multiple non-coding Ribonucleic Acids (ncRNAs) could play a potential role in An.
View Article and Find Full Text PDFThe effect of synergists on the inhibition of detoxification enzyme activities and acaricide sensitivity in Rhizoglyphus robini.
Exp Appl Acarol
December 2024
Department of Plant Protection, Faculty of Agriculture, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran.
The saffron bulb mite, Rhizoglyphus robini Claparede (Acari: Acaridae), is the most important pest of the saffron crop in Iran. This pest attacks and feeds on saffron corms. For this reason, the corms are treated with acaricides before planting.
View Article and Find Full Text PDFLandscaping DNA binding potential of piperine derivatives by computational and biophysical methods.
Int J Biol Macromol
January 2025
Department of Molecular Biology, Kannur University, Kannur, Kerala 670661, India. Electronic address:
Piperine, the alkaloid from Black pepper, is known for its wide range of pharmacological effects. The DNA binding activity of piperine was reported earlier. In this work, we explore the DNA duplex binding properties of four piperine derivatives, piperonal, piperonyl alcohol, piperonylic acid, and piperic acid using biophysical and computational techniques.
View Article and Find Full Text PDFPower calculation for mosquito bioassays: Quantifying variability in the WHO tube bioassay and developing sample size guidance for the PBO synergism assay using a Shiny application.
Gates Open Res
November 2024
Innovation To Impact (I2I), Department of Vector Biology, Liverpool, Liverpool, L35QA, UK.
Background: The WHO tube bioassay is a method for exposing mosquitos to determine susceptibility to insecticides, with mortality to discriminating doses <98% indicating possible resistance and <90% confirming resistance. This bioassay is also used for synergism testing to assess if susceptibility is restored by pre-exposure to the synergist piperonyl butoxide.
Methods: Here we perform testing with pyrethroid-susceptible and pyrethroid-resistant to quantify the variability of the WHO tube bioassay and identify its sources.
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