Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Senolysis by GLS1 Inhibition Ameliorates Kidney Aging by Inducing Excessive mPTP Opening through MFN1.
J Gerontol A Biol Sci Med Sci
December 2024
Division of Nephrology, Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Cellular senescence is a pivotal contributor to aging and age-related diseases. The targeted elimination of senescent cells, known as senolysis, has emerged as a promising therapeutic strategy for mitigating these conditions. Glutaminase 1 (GLS1), a key enzyme in the glutaminolysis pathway, has been implicated in various cellular senescence processes.
View Article and Find Full Text PDFExpansions and contractions of tandem DNA repeats are a source of genetic variation in human populations and in human tissues: some expanded repeats cause inherited disorders, and some are also somatically unstable. We analyzed DNA sequence data, derived from the blood cells of >700,000 participants in UK Biobank and the Research Program, and developed new computational approaches to recognize, measure and learn from DNA-repeat instability at 15 highly polymorphic CAG-repeat loci. We found that expansion and contraction rates varied widely across these 15 loci, even for alleles of the same length; repeats at different loci also exhibited widely variable relative propensities to mutate in the germline versus the blood.
View Article and Find Full Text PDFω-Amidase and Its Substrate α-Ketoglutaramate (the α-Keto Acid Analogue of Glutamine) as Biomarkers in Health and Disease.
Biochemistry (Mosc)
October 2024
LiT Biosciences, Spokane, WA, 99202-5029, USA. ARRAY(0x5d17383a0090).
A large literature exists on the biochemistry, chemistry, metabolism, and clinical importance of the α-keto acid analogues of many amino acids. However, although glutamine is the most abundant amino acid in human tissues, and transamination of glutamine to its α-keto acid analogue (α-ketoglutaramate; KGM) was described more than seventy years ago, little information is available on the biological importance of KGM. Herein, we summarize the metabolic importance of KGM as an intermediate in the glutamine transaminase - ω-amidase (GTωA) pathway for the conversion of glutamine to anaplerotic α-ketoglutarate.
View Article and Find Full Text PDFFerroptosis-associated genes and compounds in renal cell carcinoma.
Front Immunol
October 2024
Department of Pharmaceutical Management, School of Medical Business, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Article Synopsis
- - Clear cell renal cell carcinoma (ccRCC) is closely linked to VHL gene mutations, which affect tumor metabolism and promote factors involved in cell death pathways, such as ferroptosis, potentially revealing new treatment options.
- - Alterations in biological metabolites, particularly iron and lipids, play a crucial role in ferroptosis, and targeting these pathways with specific inhibitors could enhance the effectiveness of current treatments like immunotherapy and targeted therapy for ccRCC.
- - While ferroptosis could be a promising therapeutic strategy due to its impact on tumor immunity, it also brings potential risks by possibly aiding cancer growth, suggesting a need for further research into its complex interactions in RCC treatment.
The Anti-proliferative Effect of a Novel Glutaminase Inhibitor IN-3 on Prostate Cancer Cells.
Medeni Med J
September 2024
Istanbul Medeniyet University, Science and Advanced Technologies Research Center (BILTAM), Istanbul, Türkiye.
Objective: This study aimed to evaluate anti-cancer potential of a novel glutaminase (GLS) inhibitor IN-3 in prostate cancer cells.
Methods: The cell viability upon IN-3 treatment was examined using crystal violet staining and IC values were calculated for cancer cell lines PC-3 and LNCaP and normal fibroblasts CCD1072sk. The expression levels of GLS isoforms were determined by real-time polymerase chain reaction after IN-3 treatment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!