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Defects in the Mitochondrial Genome of Dogs with Recurrent Tumours.
Int J Mol Sci
December 2024
Institute of Biological Bases of Animal Production, University of Life Sciences in Lublin, Akademicka 13 St., 20-950 Lublin, Poland.
This study presents a comprehensive analysis of mitochondrial DNA (mtDNA) variations in dogs diagnosed with primary and recurrent tumours, employing Oxford Nanopore Technologies (ONT) for sequencing. Our investigation focused on mtDNA extracted from blood and tumour tissues of three dogs, aiming to pinpoint polymorphisms, mutations, and heteroplasmy levels that could influence mitochondrial function in cancer pathogenesis. Notably, we observed the presence of mutations in the D-loop region, especially in the VNTR region, which may be crucial for mitochondrial replication, transcription, and genome stability, suggesting its potential role in cancer progression.
View Article and Find Full Text PDFThe combination of microwave hyperthermia with TIPE2 impedes the growth of orthotopic colon cancer.
Int J Radiat Biol
January 2025
Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, China.
Background: Colon cancer (CC) is the main fatal disease of humans. Microwave hyperthermia (MH) is an adjuvant therapy for diverse cancers. Tumor necrosis factor-α induced protein-8-like 2 (TIPE2) is a tumor suppressor.
View Article and Find Full Text PDFImproving plan quality in cervical cancer brachytherapy using knowledge-based planning for direction modulated brachytherapy tandem applicator.
Brachytherapy
January 2025
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA. Electronic address:
Purpose: The bladder and rectal toxicities in cervical cancer brachytherapy are positively correlated with the DVH parameter: D2cc. This study evaluates the feasibility of knowledge-based planning to predict the D2cc, identify suboptimal plans, and improve the plan quality with Direction Modulated Brachytherapy (DMBT) applicators using knowledge-based planning based on linear relationship between overlap distances and D2cc.
Methods: The overlap volume histogram (OVH) method was used to determine the distances for 2 cm of overlap between the Organs at Risks (OAR) and High-Risk Clinical Target Volume (CTV).
Enhancing Estimation Accuracy of Prostate Cancer VMAT Planning: A Knowledge-based Approach Using Multiple Collimator Angles.
Anticancer Res
December 2024
Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, Osaka, Japan.
Article Synopsis
- * Five healthcare institutions tested this model on prostate cancer treatments, comparing how well each model could estimate dosimetric parameters and plan quality.
- * Results showed the Multi-coll. model was more accurate in its estimates and provided better plan quality, particularly in reducing radiation exposure to the rectum and bladder.
Knowledge-based planning for fully automated radiation therapy treatment planning of 10 different cancer sites.
Radiother Oncol
January 2025
Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Article Synopsis
- Radiation treatment planning is complicated and can vary significantly between different planners, but knowledge-based planning (KBP) aims to streamline the process and produce high-quality plans regardless of the planner's skills.
- The study involved creating and validating 10 automated KBP models for various treatment sites, which incorporated advanced planning scripts and optimization techniques to operate without human input.
- The results showed that 88% of the automated plans were deemed "acceptable as is" by physicians, indicating that this approach could significantly improve the efficiency and consistency of radiation treatment planning.
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