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Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course.
Circ Genom Precis Med
January 2025
Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston. (S.M.U., K.P., B.T., A.C.F., P.N.).
Background: Earlier identification of high coronary artery disease (CAD) risk individuals may enable more effective prevention strategies. However, existing 10-year risk frameworks are ineffective at earlier identification. We sought to understand how the variable importance of genomic and clinical factors across life stages may significantly improve lifelong CAD event prediction.
View Article and Find Full Text PDFFully automated coronary artery calcium score and risk categorization from chest CT using deep learning and multiorgan segmentation: A validation study from National Lung Screening Trial (NLST).
Int J Cardiol Heart Vasc
February 2025
Department of Radiology, Frimley Park Hospital NHS Foundation Trust, Camberley, Surrey, UK.
Background: The National Lung Screening Trial (NLST) has shown that screening with low dose CT in high-risk population was associated with reduction in lung cancer mortality. These patients are also at high risk of coronary artery disease, and we used deep learning model to automatically detect, quantify and perform risk categorisation of coronary artery calcification score (CACS) from non-ECG gated Chest CT scans.
Materials And Methods: Automated calcium quantification was performed using a neural network based on Mask regions with convolutional neural networks (R-CNN) for multiorgan segmentation.
The impact of self-care training using the teach-back method on health anxiety in patients with coronary artery disease: A randomized controlled clinical trial.
J Educ Health Promot
December 2024
Department of Nursing, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.
Background: Coronary artery disease (CAD) is the most prevalent heart disease and a leading cause of death among both men and women. It is worth noting that anxiety is highly prevalent among patients with CAD, and it can significantly affect their overall performance and well-being. This study aimed to determine the impact of self-care training, specifically using the teach-back method, on health anxiety in patients with CAD.
View Article and Find Full Text PDFAssociation between white blood cell count and coronary artery bypass graft failure: an individual patient data analysis of clinical trials.
J Cardiothorac Surg
January 2025
Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 E 68th St, New York, NY, 10065, USA.
Background: Baseline systemic inflammation is associated with worse long-term outcomes after coronary artery bypass grafting [CABG], but the mechanisms of this association are unclear. This study aims to explore the association between pre-operative white blood cell [WBC] count and CABG graft failure.
Methods: We pooled individual patient data from two randomized clinical trials with systematic CABG graft imaging.
Effect of rapamycin-eluting stents on in-stent restenosis and early inflammatory response in coronary artery narrowing animal models.
J Cardiothorac Surg
January 2025
The First Department of Cardiology, Beidahuang Industry Group General Hospital, Harbin, 150000, Heilongjiang Province, China.
Objective: it was to evaluate the efficacy and safety of rapamycin-eluting stents at different doses in the treatment of coronary artery narrowing in miniature pigs.
Methods: a total of 20 miniature pigs were randomly assigned into four groups: S1 group (low-dose rapamycin-coated stent, 55 µg/mm), S2 group (medium-dose rapamycin-coated stent, 120 µg/mm), S3 group (high-dose rapamycin-coated stent, 415 µg/mm), and D0 group (bare metal stent). The stent size was 3.
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