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Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research.
Viruses
January 2025
School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Coronavirus epidemics have posed a serious threat to both human and animal health. To combat emerging infectious diseases caused by coronaviruses, various animal infection models have been developed and applied in research, including non-human primate models, ferret models, hamster models, mouse models, and others. Moreover, new approaches have been utilized to develop animal models that are more susceptible to infection.
View Article and Find Full Text PDFPharmaceutical Humanities and Narrative Pharmacy: An Emerging New Concept in Pharmacy.
Pharmaceuticals (Basel)
January 2025
Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
The complexity of our life experiences and the rapid progress in science and technology clearly necessitate reflections from the humanities. The ever-growing intersection between science and society fosters the emergence of novel interdisciplinary fields of research. During the past decade, Medical Humanities arose to meet the need to unravel hidden information beyond technology-driven and fact-based medicine.
View Article and Find Full Text PDFHBV cccDNA: The Molecular Reservoir of Hepatitis B Persistence and Challenges to Achieve Viral Eradication.
Biomolecules
January 2025
Department of Gastroenterology and Hepatology, Erasmus Medical Center, Wytemaweg 80, 3015CN Rotterdam, The Netherlands.
Hepatitis B virus (HBV) is a major global health issue, with an estimated 254 million people living with chronic HBV infection worldwide as of 2022. Chronic HBV infection is the leading cause of cirrhosis and liver cancer. Current treatment with nucleos(t)ide analogs is effective in the suppression of viral activity but generally requires lifelong treatment.
View Article and Find Full Text PDFRemediating Cambridge: Human and Horse Co-Relationality in a Culture of Mis-Re-Presentation.
Animals (Basel)
January 2025
English Literary Studies, School of Humanities, Arts and Social Sciences (HASS), University of New England, Armidale, NSW 2351, Australia.
This case study aims to problematise concepts of equine and human co-relational agency in the context of 'mis-re-presentations' in the Australian media of harms experienced by the Anglo Arab stallion, Cambridge, following his development of laminitis and his consequent confinement at a leading national Equestrian centre. Autoethnographic narrative is used to retrospectively and selectively narrate the evolving relationship between Cambridge and his owners, farrier, and treating veterinarians within the dominant housing and veterinary practices and welfare paradigms in equestrian culture of 1990's Australia. Structured author/owner autoethnographic vignettes are framed by newspaper and internet reportage to highlight a productive tension between the public mediation of the case, and what it means to be fully embodied in relationship with an equine companion agent within a particular, racialised, gendered, and biopoliticised location.
View Article and Find Full Text PDFThe Immune-Genomics of Cholangiocarcinoma: A Biological Footprint to Develop Novel Immunotherapies.
Cancers (Basel)
January 2025
Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
Cholangiocarcinoma (CCA) represents approximately 3% of all gastrointestinal cancers and is a highly heterogeneous and aggressive malignancy originating from the epithelial cells of the biliary tree. CCA is classified by anatomical location into intrahepatic (iCCA), extrahepatic (eCCA), gallbladder cancer (GBC), and ampullary cancers. Although considered a rare tumor, CCA incidence has risen globally, particularly due to the increased diagnosis of iCCA.
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