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Anaesthetic practice and mortality in Scotland compared to England from 1847 to 1914.
Anaesth Intensive Care
February 2025
Science, Technology and Innovation Studies, School of Social and Political Science, University of Edinburgh, Edinburgh, UK.
In the second half of the nineteenth century and up to the First World War, anaesthetic practice in Scotland differed markedly from that in England. Chloroform was invariably used in Scotland with apparent disregard for reports of deaths under its influence. By contrast, in England concern about chloroform deaths, which were subject to inquests there, led to ether often being chosen instead.
View Article and Find Full Text PDF[Effect of electroacupuncture on neurological function in rats with cerebral ischemia-reperfusion injury based on AMPK/mTOR/ULK1 signaling pathway].
Zhongguo Zhen Jiu
December 2024
Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of CM, Guangzhou 510006, Guangdong Province, China; Second Clinical College of Guangzhou University of CM, Guangzhou 510120, Guangdong Province; Department of Rehabilitation, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120; Guangdong Provincial Key Laboratory of TCM Prevention and Treatment of Intractable Chronic Diseases, Guangzhou 510120.
Objective: To investigate the effect of electroacupuncture (EA) on neurological function in rats with cerebral ischemia-reperfusion injury (CIRI) by regulating adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/Unc-51-like kinase 1 (ULK1) signaling pathway.
Methods: Thirty-three male SD rats were randomly divided into a sham-operation group, a model group and an EA group, with 11 rats in each group. The right middle cerebral artery occlusion/reperfusion (MCAO/R) model was prepared by thread occlusion method in the model group and the EA group.
Horace Wells: A Pioneer in Modern Anesthesia and Pain-Free Medical Practices.
Cureus
October 2024
Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to Be University) Dental College and Hospital, Navi Mumbai, IND.
Horace Wells, a pioneering figure in the field of anesthesia, was born on January 21, 1815, in Hartford, Vermont. He is widely recognized for his groundbreaking discovery of the anesthetic properties of nitrous oxide, a finding that revolutionized pain management in both medical and dental procedures. Wells' contribution marked a pivotal moment in the history of surgery, transforming it from a traumatic, painful ordeal to a more humane and tolerable practice.
View Article and Find Full Text PDFEvaluation of concurrent use of Vitamin C and Niclosamide against methotrexate-induced liver injury in mice.
J Pak Med Assoc
October 2024
Department of Clinical Pharmacology, Mustansiriyah University, Baghdad, Iraq.
Objective: To examine the effect of using vitamin C and niclosamide together on liver damage caused by methotrexate.
Methods: The study was conducted at the Pharmacology Department and the Iraqi Center for Cancer and Medical Genetics Research, College of Medicine, Mustansiriya University, Baghdad, Iraq, from November 2020 to July 2021, and comprised albino mice who were randomly assigned to 5 groups. Group 1 comprised controls, groups 2 to 5 was received methotrexate, niclosamide 70mg/kg/day, vitamin C 100mg/kg/day, and a combination of niclosamide and vitamin C, respectively.
Evaluation the effects of Omega-3 and vitamin C alone or in combination on Methotrexate-Induced hepatotoxicity (in mice).
J Pak Med Assoc
October 2024
Department of Pharmacology, Mustansiriyah University, Baghdad, Iraq.
Article Synopsis
- The study aimed to evaluate how omega-3 and vitamin C pretreatment affects liver damage caused by methotrexate in mice.
- Swiss albino mice were divided into five groups, with some receiving methotrexate and others receiving omega-3, vitamin C, or a combination before the methotrexate was administered.
- Results showed that pretreatment with omega-3 and vitamin C significantly reduced liver toxicity, supporting their protective antioxidant properties.
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