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FRAX, a risk calculator that provides individualized 10-year probabilities of hip and major osteoporotic fracture, has been widely used for fracture risk assessment since its launch in 2008. It is now incorporated into very many guidelines worldwide to inform osteoporosis management. In this review, we explore the development of FRAX and how it enhances fracture risk prediction as compared to use of bone mineral density alone, as well as approaches to utilizing FRAX in determining intervention and assessment thresholds.

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The application of neonicotinoid insecticides (NEOs) increases the potential exposure risks and has an impact on the aroma quality of tomato fruits. Here, 3D cornflower-like MoS (MoS-CF) was fabricated to directly activate peroxymonosulfate (PMS) for fast removal of three typical NEOs. The 3D MoS-CF catalyst achieved over 96.

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The effects of estrogen depletion in female rats: differential influences on somato-motor and sensory cortices.

Biogerontology

January 2025

Department of Anatomy, College of Medicine, Tzu Chi University, No. 701, Section 3, Zhongyang Rd., Hualien, 970374, Taiwan.

Aging women experience a significant decline of ovarian hormones, particularly estrogen, following menopause, and become susceptible to cognitive and psychomotor deficits. Although the effects of estrogen depletion had been documented in the prefrontal and somatosensory cortices, its impact on somatomotor cortex, a region crucial for motor and cognitive functions, remains unclear. To explore this, we ovariectomized young adult female rats and fed subsequently with phytoestrogen-free diet and studied the effects of estrogen depletion on the somato-sensory and motor cortices.

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Cellular dynamics of cervical remodelling: insights from preterm and term labour.

Arch Gynecol Obstet

January 2025

Department of Pathology, Instituto Português de Oncologia do Porto, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.

Introduction: Preterm birth remains a global health challenge with significant perinatal morbidity and mortality rates. Despite extensive research, the underlying mechanisms triggering preterm birth remain elusive, needing a deeper understanding of cervical cellular remodelling processes.

Purpose: This study aims to elucidate the cellular mechanisms underlying cervical remodelling in spontaneous preterm labour (PTL) compared to term labour (TL), focusing on the roles of inflammatory cells and fibroblasts.

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Accumulation of plastic waste is an alarming environmental concern across globe. For which, microbial degradation offers an efficient ecofriendly solution. Thus, the present study focuses on the exploration of new bacterium that can grow on and utilize polyethylene.

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