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Clinically Suspicious Cases of Hansen's Disease at a Tertiary Care Hospital in South India: A Clinicopathological Study.
Cureus
October 2024
Department of Dermatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Background and objective Hansen's disease, also known as leprosy, is a chronic granulomatous condition caused by , primarily affecting the skin and peripheral nerves. The disease has a wide spectrum of clinical and histopathological manifestations, often mimicking other inflammatory and infectious conditions. This variability poses significant challenges in its early diagnosis and management.
View Article and Find Full Text PDFCellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics.
EBioMedicine
October 2024
Hospital for Skin Diseases, Shandong First Medical University, Shandong, China; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Shandong, China. Electronic address:
Background: Which cell populations that determine the fate of bacteria in infectious granulomas remain unclear. Leprosy, a granulomatous disease with a strong genetic predisposition, caused by Mycobacterium leprae infection, exhibits distinct sub-types with varying bacterial load and is considered an outstanding disease model for studying host-pathogen interactions.
Methods: We performed single-cell RNA and immune repertoire sequencing on 11 healthy controls and 20 patients with leprosy, and integrated single-cell data with genome-wide genetic data on leprosy.
qPCR detection of DNA in urine samples of leprosy patients using the gene target.
Front Mol Biosci
August 2024
Department of Biotechnology, Thiruvalluvar University, Vellore, India.
Background: Leprosy, a chronic infectious disease caused by , continues to pose a public health challenge in many parts of the world. Early and accurate diagnosis is crucial for effective treatment and prevention of disabilities associated with the disease. Molecular techniques such as PCR have demonstrated great potential as a diagnostic tool for directly detecting DNA in different clinical samples, providing better sensitivity and specificity than conventional diagnostic techniques.
View Article and Find Full Text PDFInvestigation of the fungiform papillae number in children with tooth number anomalies.
Clin Oral Investig
May 2024
Department of Pediatric Dentistry, Faculty of Dentistry, Marmara University, Istanbul, Turkey.
Objective: This cross-sectional study investigated the association between fungiform papillae (FP) numbers and tooth number anomalies in children, considering variables related to hypodontia and hyperdontia. The aim was to explore this association while adjusting for age and sex differences.
Materials And Methods: A total of 144 children (aged 8-10) were categorized into hypodontia (n = 48), hyperdontia (n = 48), and control groups (n = 48).
The plasma kynurenine-to-tryptophan ratio as a biomarker of tuberculosis disease in people living with HIV on antiretroviral therapy: an exploratory nested case-control study.
BMC Infect Dis
April 2024
Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers Location University of Amsterdam, Amsterdam, The Netherlands.
Article Synopsis
- Non-sputum-based tests are crucial for diagnosing tuberculosis (TB) in people living with HIV (PWH), and the Kyn-to-Trp (K/T) plasma ratio may serve as a promising biomarker to predict TB disease in these patients on antiretroviral therapy (ART).
- The study measured K/T ratios at three different time points (at diagnosis, 6 months before, and 6 months after) in PWH who developed TB, revealing significantly higher ratios at diagnosis compared to matched controls.
- Following successful TB treatment, K/T ratios significantly dropped, but they increased in cases of treatment failure, suggesting the ratio could be useful for monitoring TB treatment in PWH, pending further validation studies.
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