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Crystalline Silica-Induced Proinflammatory Interstitial Macrophage Recruitment through Notch3 Signaling Promotes the Pathogenesis of Silicosis.
Environ Sci Technol
October 2023
Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, (China Medical University), Ministry of Education, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China.
Crystalline silica (CS) particles are ubiquitous in the environment, especially in occupational conditions, and exposure to respirable CS causes silicosis. The initial response to CS is mediated by innate immunity, where pulmonary macrophages act as central orchestrators. However, the repercussions of CS on functionally distinct macrophage subsets remain to be inconclusive.
View Article and Find Full Text PDF[Other pneumoconioses].
J Bras Pneumol
September 2007
Universidade Estadual de Campinas, Campinas, SP, Brasil.
The most prevalent pneumoconioses are silicosis, asbestosis and coal worker's pneumoconiosis. Other pneumoconioses that have distinct clinical, functional and structural repercussions are caused by inhalation of metal powder in fumes from metals or organic salts. The distinction in terms of the chemical form of the inhaled compound is related to the tissue reaction and to the prognosis.
View Article and Find Full Text PDF[Erasmus syndrome: clinical, tomographic, respiratory function and bronchoalveolar lavage characteristics].
Rev Mal Respir
January 1997
Service de Médecine du Travail, CHRU de Lille.
The Erasmus syndrome describes the association of generalised progressive scleroderma following exposure to silica with or without silicosis. This is a case report on four patients presenting with the Erasmus syndrome who were admitted to hospital. The analysis of the four cases enables an assessment of the cause of the dyspnoea during the course of the Erasmus syndrome.
View Article and Find Full Text PDF[Pulmonary functional repercussions of simple forms of anthraco-silicosis].
Acta Tuberc Pneumol Belg
November 1977
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