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The Interaction Between Vowel Quality and Intensity in Loudness Perception of Short Vowels in Mongolian.
J Speech Lang Hear Res
January 2025
School of Humanities, Shenzhen University, China.
Purpose: This study investigated the influence of vowel quality on loudness perception and stress judgment in Mongolian, an agglutinative language with free word stress. We aimed to explore the effects of intrinsic vowel features, presentation order, and intensity conditions on loudness perception and stress assignment.
Method: Eight Mongolian short vowel phonemes (/ɐ/, /ə/, /i/, /ɪ/, /ɔ/, /o/, /ʊ/, and /u/) were recorded by a native Mongolian speaker of the Urad subdialect (the Chahar dialect group) in Inner Mongolia.
Comparative Structural and Biophysical Investigation of Toxin I (LyeTx I) and Its Analog LyeTx I-b.
Antibiotics (Basel)
January 2025
Departamento de Química, Faculdade de Ciências Exatas, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Campus JK, Diamantina 39100-000, MG, Brazil.
This study investigates the structural and biophysical properties of the wild-type antimicrobial peptide LyeTx I, isolated from the venom of the spider , and its analog LyeTx I-b, designed to enhance antibacterial activity, selectivity, and membrane interactions by the acetylation and increased amphipathicty. : To understand the mechanisms behind these enhanced properties, comparative analyses of the structural, topological, biophysical, and thermodynamic aspects of the interactions between each peptide and phospholipid bilayers were evaluated. Both peptides were isotopically labeled with H-Ala and N-Leu to facilitate structural studies via NMR spectroscopy.
View Article and Find Full Text PDFCharacterization of a novel allele harboring a c.28 + 5G>A mutation on the background: a study utilizing PacBio third-generation sequencing and functional assays.
Front Immunol
January 2025
Blood Group Reference Laboratory, Dalian Blood Center, Dalian, China.
Background: Mutations in the ABO gene, including base insertions, deletions, substitutions, and splicing errors, can result in blood group subgroups associated with the quantity and quality of blood group antigens. Here, we employed third-generation PacBio sequencing to uncover a novel allele arising from an intron splice site mutation, which altered the expected A phenotype to manifest as an Ael phenotype. The study aimed to characterize the molecular mechanism underlying this phenotypic switch.
View Article and Find Full Text PDFExcess Ub-K48 Induces Neuronal Apoptosis in Alzheimer's Disease.
J Integr Neurosci
December 2024
Department of Human Anatomy, School of Basic Medical Sciences, Wannan Medical College, 241002 Wuhu, Anhui, China.
Background: K48-linked ubiquitin chain (Ub-K48) is a crucial ubiquitin chain implicated in protein degradation within the ubiquitin-proteasome system. However, the precise function and molecular mechanism underlying the role of Ub-K48 in the pathogenesis of Alzheimer's disease (AD) and neuronal cell abnormalities remain unclear. The objective of this study was to examine the function of K48 ubiquitination in the etiology of AD, and its associated mechanism of neuronal apoptosis.
View Article and Find Full Text PDFDevelopment of monoclonal antibodies against Mfa1 and their protective capacity in an experimental periodontitis model.
mSphere
January 2025
Joint National Laboratory for Antibody Drug Engineering, School of Medicine, Henan University, Kaifeng, China.
Article Synopsis
- The text discusses the significance of the Mfa1 fimbriae protein in a gram-negative anaerobe that causes periodontitis and highlights its potential as a therapeutic target.
- The study developed monoclonal antibodies (mAbs) against Mfa1 which showed effectiveness in reducing bacterial infection and inflammation in experimental models of periodontitis.
- Results indicate that anti-Mfa1 mAbs could serve as valuable tools for both diagnosing and treating Mfa1-related infections and diseases, paving the way for improved therapeutic strategies.
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