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Calculating indirect costs from international PEPFAR implementing partners.
PLoS One
April 2019
amfAR, the Foundation for AIDS Research, Washington, DC, United States.
Background: UNAIDS estimates global HIV investment needs in low- and middle-income countries (LMICs) at $26 billion per year in 2020. Yet international financing for HIV programs has stagnated amidst despite the increasing number of people requiring and accessing treatment. Despite increased efficiencies in HIV service delivery, evaluating programs for greater efficiencies remains necessary.
View Article and Find Full Text PDFElectron tomography of whole cultured cells using novel transmission electron imaging technique.
Micron
January 2018
Hitachi, Ltd., Research & Development Group, 2520, Akanuma, Hatoyama, Saitama, 350-0395 Japan.
Since a three-dimensional (3D) cellular ultrastructure is significant for biological functions, it has been investigated using various electron microscopic techniques. Although transmission electron microscopy (TEM)-based techniques are traditionally used, cells must be embedded in resin and sliced into ultrathin sections in sample preparation processes. Block-face observation using a scanning electron microscope (SEM) has also been recently applied to 3D observation of cellular components, but this is a destructive inspection and does not allow re-examination.
View Article and Find Full Text PDFDeveloping the Clarity and Openness in Reporting: E3-based (CORE) Reference user manual for creation of clinical study reports in the era of clinical trial transparency.
Res Integr Peer Rev
May 2016
European Medical Writers Association, Chester House, 68 Chestergate, Macclesfield, Cheshire SK11 6DY UK.
Background: Interventional clinical studies conducted in the regulated drug research environment are reported using International Council for Harmonisation (ICH) regulatory guidance documents: ICH E3 on the structure and content of clinical study reports (CSRs) published in 1995 and ICH E3 supplementary Questions & Answers (Q & A) published in 2012.Since the ICH guidance documents were published, there has been heightened awareness of the importance of disclosure of clinical study results. The use of the CSR as a key source document to fulfil emerging obligations has resulted in a re-examination of how ICH guidelines are applied in CSR preparation.
View Article and Find Full Text PDFCurriculum reform for residency training: competence, change, and opportunities for leadership.
Can J Anaesth
July 2016
Department of Anesthesiology, The Ottawa Hospital/The University of Ottawa, Ottawa Civic Hospital, Suite B302, 1053 Carling Avenue, Ottawa, ON, K1Y 4E2, Canada.
Purpose: Certain pressures stemming from within the medical community and from society in general, such as the need for increased accountability in resident training and restricted resident duty hours, have prompted a re-examination of methods for training physicians. Leaders in medical education in North America and around the world champion competency-based medical education (CBME) as a solution. The Department of Anesthesiology at the University of Ottawa launched Canada's first CBME program for anesthesiology residents on July 1, 2015.
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