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Diagnostic performance of hepatitis C virus core antigen testing for detecting hepatitis C in people living with hepatitis B: a systematic review and meta-analysis.

Infect Dis Poverty

December 2024

Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología - Instituto de Salud Carlos III, Km 2.2, 28220, Majadahonda (Madrid), Spain.

Background: The current diagnostic strategy for hepatitis C virus (HCV) infection involves a two-step approach: antibody HCV screening followed by confirmatory nucleic acid testing. This study aimed to evaluate the diagnostic performance of the Abbott ARCHITECT HCV Ag assay in serum/plasma samples as a potential one-step alternative for diagnosing active HCV infection in people living with hepatitis B virus (PLWHB) through a systematic review and meta-analysis.

Methods: A systematic review and meta-analysis were conducted following PRISMA-DTA guidelines.

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Aim: Aim of the pilot was to increase HIV/HCV/syphilis testing and linkage to care of newly diagnosed persons, improve data collection and transfer using standard data collection tools in CBVCT services.

Methods: Integrated anonymous voluntary testing from blood for HIV, HCV and syphilis was realised using rapid tests in the period of 6 months (03/2019-08/2019). Participants with reactive results were advised to see a specialist for confirmatory testing and/or treatment.

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Dried blood spot (DBS) sampling is increasingly used for hepatitis C virus (HCV) screening. HCVcAg testing offers a faster and more streamlined approach to diagnosing HCV infection. We conducted a systematic review and meta-analysis to assess the diagnostic performance of the Abbott ARCHITECT HCV Ag assay for screening active HCV infection using DBS samples.

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Article Synopsis
  • There is a growing need for faster detection of sexually transmitted blood-borne infections (STBBIs), leading to the development of digital innovations like AideSmart!, an app that supports multiplexed testing by health care workers in community settings.
  • The study aimed to evaluate AideSmart! for its feasibility and impact, allowing healthcare providers to perform rapid STBBI tests while offering counseling and ensuring quality care.
  • Results showed that all participants accepted the app's testing strategy, with a majority preferring rapid tests to traditional methods and valuing the quick turnaround of results, which took only 15 minutes.
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Article Synopsis
  • Hepatitis C virus (HCV) is a significant public health issue in China, impacting over 10 million people, prompting the HEAL program, which aimed to improve HCV surveillance and linkage to care in tertiary hospitals.
  • The intervention included education for non-infectious disease physicians and a patient-navigator system to streamline testing and treatment for patients who tested positive for HCV.
  • Following the HEAL program implementation, screening rates and follow-up for HCV increased significantly, leading to a higher number of confirmed active infections and improved patient linkage to care.
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