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Diagnostic performance of hepatitis C virus core antigen testing for detecting hepatitis C in people living with hepatitis B: a systematic review and meta-analysis.
Infect Dis Poverty
December 2024
Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología - Instituto de Salud Carlos III, Km 2.2, 28220, Majadahonda (Madrid), Spain.
Article Synopsis
- The study evaluated the Abbott ARCHITECT HCV Ag assay as a potential one-step diagnostic tool for active hepatitis C virus (HCV) infection in individuals co-infected with hepatitis B virus (PLWHB), comparing it to standard two-step methods.
- It involved a systematic review and meta-analysis of ten studies with 494 participants, showing that the Abbott assay had high sensitivity (91%) and specificity (99%), making it effective for diagnosing active HCV, particularly in high-prevalence settings.
- Despite its effectiveness, confirmatory testing is still recommended in low-prevalence areas to ensure accuracy.
Aim: Aim of the pilot was to increase HIV/HCV/syphilis testing and linkage to care of newly diagnosed persons, improve data collection and transfer using standard data collection tools in CBVCT services.
Methods: Integrated anonymous voluntary testing from blood for HIV, HCV and syphilis was realised using rapid tests in the period of 6 months (03/2019-08/2019). Participants with reactive results were advised to see a specialist for confirmatory testing and/or treatment.
Diagnostic performance of dried blood spot hepatitis C virus core antigen testing for hepatitis C screening: A systematic review and meta-analysis.
J Med Virol
October 2024
Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
Article Synopsis
- Dried blood spot (DBS) sampling is becoming popular for hepatitis C virus (HCV) screening, with HCVcAg testing providing quick diagnostics for active infections.
- A systematic review analyzed eight studies (totaling 1,229 participants) and found that the Abbott ARCHITECT HCV Ag assay had 85% sensitivity and 100% specificity when compared to the gold standard HCV PCR test.
- The assay is highly accurate (over 92%) in high-prevalence settings, but in low-prevalence areas, positive results require confirmation through another test due to the potential for misleading outcomes.
Feasibility, Preference, and Impact of a Rapid Multiplexed Point-of-Care Digital Innovation (AideSmart!) to Expedite Screening of Sexually Transmitted Blood-Borne Infections in At-Risk Populations in Canada: Cross-Sectional Study.
J Med Internet Res
October 2024
Infectious Diseases and Immunity in Global Health, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Article Synopsis
- There is a growing need for faster detection of sexually transmitted blood-borne infections (STBBIs), leading to the development of digital innovations like AideSmart!, an app that supports multiplexed testing by health care workers in community settings.
- The study aimed to evaluate AideSmart! for its feasibility and impact, allowing healthcare providers to perform rapid STBBI tests while offering counseling and ensuring quality care.
- Results showed that all participants accepted the app's testing strategy, with a majority preferring rapid tests to traditional methods and valuing the quick turnaround of results, which took only 15 minutes.
A Programme of Hepatitis C Surveillance With Active Linkage to Care (HEAL) for Inpatients in Two Tertiary Hospitals in Jiangsu, China.
J Viral Hepat
October 2024
Institute of Viruses and Infectious Diseases, Nanjing University, Jiangsu, China.
Article Synopsis
- Hepatitis C virus (HCV) is a significant public health issue in China, impacting over 10 million people, prompting the HEAL program, which aimed to improve HCV surveillance and linkage to care in tertiary hospitals.
- The intervention included education for non-infectious disease physicians and a patient-navigator system to streamline testing and treatment for patients who tested positive for HCV.
- Following the HEAL program implementation, screening rates and follow-up for HCV increased significantly, leading to a higher number of confirmed active infections and improved patient linkage to care.
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