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A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade.
BMC Rheumatol
January 2025
Department of Rheumatology, Overton Brooks VA Medical Center, Shreveport, LA, USA.
Background: Dermatomyositis is a chronic inflammatory condition affecting muscles and skin, often associated with an increased risk of cancer. Specific autoantibodies, including anti-TIF1 (Transcription Intermediary Factor 1), have been linked to this risk. We present a case of dermatomyositis in a male patient positive for anti-TIF1 antibodies, subsequently diagnosed with squamous cell carcinoma of the tonsil, a novel association not previously documented.
View Article and Find Full Text PDFRecurrent Allergic Contact Dermatitis to Bacitracin Used in Pocket Irrigation During Breast Reconstruction Surgery.
Plast Surg (Oakv)
November 2024
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity reaction that presents as a pruritic eczematous rash occurring 24 to 48 h after allergen exposure. It is a surgical complication that can impact people's quality of life after plastic surgeries. A 44-year-old female with right breast cancer presented with three recurrent episodes of severe pruritic cutaneous eczematous eruption over her right breast extending down to her trunk and vulva each time soon after her multiple breast surgeries.
View Article and Find Full Text PDFAssociation between atopic dermatitis and prurigo nodularis: a systematic review and meta-analysis.
Int J Dermatol
February 2025
Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- Atopic dermatitis (AD) and prurigo nodularis (PN) are chronic skin conditions characterized by intense itching and eczema-like lesions, which significantly impact patients' quality of life.
- Recent research has shown a strong connection between AD and PN, with a meta-analysis revealing that individuals with PN have a much higher risk of developing AD (odds ratio of 16.85) and a notable prevalence of PN among those with AD (2.00%).
- These findings suggest a complex relationship between the two conditions that warrants further research to better understand their interactions and improve treatment approaches.
Dermatologic Conditions in Down Syndrome: A Multi-Site Retrospective Review of International Classification of Diseases Codes.
Pediatr Dermatol
November 2024
Department of Dermatology, Dartmouth Health, Manchester, New Hampshire, USA.
Article Synopsis
- As life expectancy for individuals with Down syndrome rises, this study aims to identify prevalent skin conditions throughout their lives to improve clinical care and drive research.
- Analyzing data from 1,529 patients across eight medical centers from 2011 to 2021 revealed that eczematous dermatitis is the most common skin condition, with variations by age group; children often face eczema, adolescents experience folliculitis, and adults are prone to seborrheic dermatitis.
- The findings highlight the need for focused clinical guidelines and research on skin disorders in the Down syndrome population, which predominantly include eczema and autoimmune skin diseases.
A case report of diet elimination guided by food specific IgG4 achieved clinical cure for eczematous external otitis with finger paronychia.
Medicine (Baltimore)
September 2024
Department of Allergy and Clinical Immunology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- Eczematous external otitis (EEO) is a challenging condition characterized by itchy inflammation in the external ear canal, often linked to dermatological or allergic responses, including potential food allergies, although the role of food-specific IgG4 is still not fully understood.
- A 54-year-old woman with EEO experienced persistent itching and chapped hands for several years and was treated through a diet elimination approach that removed egg, milk, and wheat, alongside probiotics, based on her food-specific IgG4 results.
- After 17 months of this treatment, she reported complete relief from symptoms, with food-specific IgG4 levels returning to normal, highlighting the potential importance of food allergens and diet in EEO management.
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