In investigations of the effect of the bronchospasmolytic (8r)-3alpha-e (ipratropiumbromide, Sch 1000, Atrovent) on the reproductive function in the mouse, rat and rabbit, no teratogenic effect was demonstrated following administration by either gavage or inhalation. Extremely high dose resulted in mortality in pregnant animals and reduction in foetal birthweight. Similarly, no evidence of impaired fertility or perinatal survival due to the substance was found. Postnatal development progressed normally.
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