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Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.
Nat Cancer
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution to the sampling bias problem by analyzing multiregion whole-exome and RNA sequencing data for 450 tumor regions from 184 patients with lung adenocarcinoma in the TRACERx study.
View Article and Find Full Text PDFThe Hypersensitive Narcissism Scale: Updated and extended construct validation in community samples using a newly constructed German version.
Psychol Assess
January 2025
Medical University of Graz, Department of Medical Psychology, Psychosomatics, and Psychotherapy.
The Hypersensitive Narcissism Scale (HSNS) is a an economical, widely used self-report measure of vulnerable narcissism. Developed and mostly used as a unidimensional scale, previous structural examinations suggest two correlated dimensions, one emphasizing hypersensitive/neurotic aspects and the other highlighting egocentric/antagonistic aspects of vulnerable narcissism. The few extant factor analyses of the HSNS, however, differ profoundly in their methodological approach, the resulting item-to-factor assignment, and lack a thorough validation of the two putative subscales.
View Article and Find Full Text PDFNeuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.
JAMA Netw Open
December 2024
Department of Psychological and Brain Sciences, Washington University in St Louis, Missouri.
Importance: The extent to which neuroanatomical variability associated with early substance involvement, which is associated with subsequent risk for substance use disorder development, reflects preexisting risk and/or consequences of substance exposure remains poorly understood.
Objective: To examine neuroanatomical features associated with early substance use initiation and to what extent associations may reflect preexisting vulnerability.
Design, Setting, And Participants: Cohort study using data from baseline through 3-year follow-up assessments of the ongoing longitudinal Adolescent Brain Cognitive Development Study.
Background: People with Down syndrome (DS) are genetically at-risk for Alzheimer's disease (AD). The age of symptomatic AD in DS varies (late-40s-70s). Lifestyle factors are theorized to explain some of this variability.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Background: A key characteristic of Alzheimer's disease (AD) is cerebral aggregation of tau. These aggregates can be quantified and localized with positron emission tomography (PET), which improves the diagnostic and prognostic work-up of AD. However, tau-PET is expensive and not available in clinical settings globally.
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