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Into the spotlight: A spatial study of potentially underreported leptospirosis among dengue-negative patients in São Paulo city, Brazil.
PLoS Negl Trop Dis
March 2025
Universidade Santo Amaro, Programa de Pós-graduação, São Paulo, Brazil.
Leptospirosis and dengue share similar unspecific symptoms, complicating differential diagnosis in endemic regions. This overlap is further exacerbated by the often-underrecognized nature of leptospirosis, resulting in low clinical suspicion among healthcare providers. Understanding the scale of underdiagnosed leptospirosis cases, particularly among dengue-negative patients, is critical for improving public health responses.
View Article and Find Full Text PDFBackground And Aim: Leptospirosis, caused by spp., affects humans and animals, posing significant health and economic burdens. This multidisciplinary One Health study aimed to estimate the prevalence of spp.
View Article and Find Full Text PDFDesign and evaluation of potent multiepitope broad spectrum DNA and protein vaccine candidates against leptospirosis.
Microb Pathog
February 2025
Gujarat Biotechnology Research Centre (GBRC), Gandhinagar, India. Electronic address:
Leptospirosis is a widespread zoonotic disease that causes severe health complications with no approved vaccine which provide broad range protection. In this study, we have focused on LruC protein from the outer membrane of Leptospira spp. LruC protein has been considered as promising target for vaccine due to its immunogenicity and conservancy.
View Article and Find Full Text PDFTLR4 competence and mouse models of leptospirosis.
bioRxiv
February 2025
Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
Mice are slowly being accepted as alternative models for investigation of leptospiral infection. The strain most used to analyse sublethal disease (C3H-HeJ) expresses a gene in its immune cells that is hyporesponsive to leptospiral LPS and thus the model is deemed immunocompromised. To help resolve this valid scientific concern we did a study in which we compared infection with serovar Copenhageni Fiocruz in mice expressing fully competent (C3H-HeN, C57BL6) versus hyporesponsive mice (C3H-HeJ) over a period of two weeks.
View Article and Find Full Text PDFProduction of recombinant electron transfer flavoprotein beta subunit protein and its application in a lateral flow assay for early diagnosis of leptospirosis.
Med Microbiol Immunol
February 2025
Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Leptospirosis is a major cause of acute febrile illness, often presenting with non-specific symptoms that can lead to misdiagnosis. Early laboratory diagnosis is essential for confirmation to avoid misdiagnosis and ensure appropriate management. This study aimed to identify and produce a recombinant protein, approximately 25 kDa, with high antigenicity for diagnostic applications.
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