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Endometriosis: Evaluation and Treatment.
Am Fam Physician
October 2022
University of California San Diego School of Medicine, San Diego, California.
Endometriosis is an inflammatory condition caused by the presence of endometrial tissue in extra-uterine locations and can involve bowel, bladder, and all peritoneal structures. It is one of the most common gynecologic disorders, affecting up to 10% of people of reproductive age. Presentation of endometriosis can vary widely, from infertility in asymptomatic people to debilitating pelvic pain, dysmenorrhea, and period-related gastrointestinal or urinary symptoms.
View Article and Find Full Text PDFSelective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus.
J Endocrinol
September 2019
Centre for Inflammation Research, The University of Edinburgh, Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
Selective androgen receptor modulators (SARMs) have been proposed as therapeutics for women suffering from breast cancer, muscle wasting or urinary incontinence. The androgen receptor (AR) is expressed in the uterus but the impact of SARMs on the function of this organ is unknown. We used a mouse model to compare the impact of SARMs (GTx-007/Andarine®, GTx-024/Enobosarm®), Danazol (a synthetic androstane steroid) and dihydrotestosterone (DHT) on tissue architecture, cell proliferation and gene expression.
View Article and Find Full Text PDF[Not Available].
Z Gerontol Geriatr
August 2016
Salzkammergut-Klinikum, Miller-von-Aichholz-Str. 49, 4810, Gmunden, Österreich.
Treatment of pain associated with deep endometriosis: alternatives and evidence.
Fertil Steril
October 2015
Unit of Obstetrics and Gynecology, San Martino Hospital and National Institute for Cancer Research, University of Genoa, Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Pain is the most evident clinical manifestation of deep infiltrating endometriosis (DIE). Several hormonal and immunologic mechanisms are markedly altered in DIE compared with superficial peritoneal and ovarian endometriosis, and may explain its most aggressive behavior and the presence of severe pain symptoms. Hormonal therapies, such as combined hormonal contraceptives and progestogens, should be regarded as first-line treatment, as they are efficacious, safe, and well tolerated.
View Article and Find Full Text PDF[Role of medical treatment for symptomatic leiomyoma management in premenopausal women].
J Gynecol Obstet Biol Reprod (Paris)
December 2011
Servie de gynécologie obstétrique, hôpital Bichat, 46, rue Henri-Huchard, 75018 Paris, France.
The most frequent symptom with leiomyoma is menometrorrhagia. However, it can be responsible of pelvic pain, dysmenorrhea or urinary and digestive compression when it is particularly voluminous. These recommandations were made in order to review medical management of fibroids.
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