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Development of a Hydrocortisone Orodispersible Thin Film Containing Its Succinate Prodrug.
Pharmaceuticals (Basel)
January 2025
Service Pharmacie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris (AP-HP), 149 Rue de Sèvres, F-75015 Paris, France.
Unlabelled: Orodispersible thin film (ODF) is an innovative dosage form that allows for adjustable dosing and improved patient compliance. It is administered by mouth, where it dissolves, making it suitable for children.
Objectives: The aim of the study was to develop and characterize an optimal ODF formulation containing equivalent hydrocortisone at 0.
Cyclodextrin Inclusion Complexes with Hydrocortisone-Type Corticosteroids.
Pharmaceutics
December 2024
Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-093 Warsaw, Poland.
The hydrocortisone-type corticosteroid (HTC) group includes valuable active pharmaceutical ingredients (APIs) such as hydrocortisone, hydrocortisone acetate, cortisone acetate, tixocortol pivalate, prednisolone, methylprednisolone, and prednisone. Unfortunately, those APIs are characterized by low solubility, which hampers their application and reduces their therapeutic efficacy. The low polarity of HTC molecules allows them to form inclusion complexes with various cyclodextrins (CDs); however, as shown in this review, the type of applied CDs has a major impact on the final properties of the formed complex.
View Article and Find Full Text PDFEffects of Different Ultrasound-Guided Nerve Block Modalities on Inflammatory Stress Response in Elderly Patients after Total Hip Arthroplasty.
Ann Ital Chir
October 2024
Department of Anesthesiology and Perioperative Medicine, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, 061001 Cangzhou, Hebei, China; Hebei Province Key Laboratory of Integrated Traditional and Western Medicine in Neurological Rehabilitation, 061000 Cangzhou, Hebei, China.
Aim: This study aimed to evaluate the impact of different ultrasound-guided nerve blocks on the postoperative inflammatory and stress response in elderly patients undergoing total hip arthroplasty (THA), providing a theoretical foundation for clinical application.
Methods: Elderly patients with THA who received ultrasound-guided nerve block combined with general anesthesia from June 2021 to June 2022 in the hospital were selected as a retrospective cohort study. Patients were divided into two groups based on the type of nerve block used.
Administration of Corticosteroids for Prompt Suppression of Cytokine Storm in Severe Cases of Japanese Spotted Fever.
Cureus
August 2024
Department of Nephrology, Yamaguchi Red Cross Hospital, Yamaguchi, JPN.
Japanese spotted fever (JSF) is a tick-borne disease caused by and primarily affects the warmer coastal areas of Japan. Early treatment with tetracycline antibiotics is crucial to prevent severe complications, such as pneumonia, meningitis, disseminated intravascular coagulation (DIC), and systemic inflammatory response syndrome. An 83-year-old man with hypertension, chronic kidney disease, and hyperuricemia presented with DIC and subsequently developed septic shock.
View Article and Find Full Text PDFPeripheral Biomarkers of Anorexia Nervosa: A Meta-Analysis.
Nutrients
June 2024
Equip Health, Inc., P.O. Box 131747, Carlsbad, CA 92013, USA.
Article Synopsis
- - This study aimed to identify biomarkers related to anorexia nervosa (AN) by analyzing data from various published studies up to mid-2022.
- - It found that certain biomarkers, like acylated ghrelin and cortisol, were significantly higher in individuals with AN, while others, such as leptin and insulin, were lower compared to non-AN controls.
- - The findings suggest that these peripheral biomarkers could be important for understanding the biological mechanisms behind AN and might lead to improved personalized treatments in the future.
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