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Infant With Beckwith-Wiedemann Requiring Transplant for Hepatic Mesenchymal Hamartoma.
Pediatr Transplant
February 2025
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Background: Liver transplantation for unresectable, benign hepatic lesions is rare. Hepatic mesenchymal hamartomas (HMH) are benign, cystic tumors that arise mostly in pediatric populations and can cause compressive symptoms. HMH is rarely associated with placental mesenchymal dysplasia (PMD) and Beckwith-Wiedemann syndrome (BWS).
View Article and Find Full Text PDFHepatic Mesenchymal Hamartoma With Elevated Alpha-Fetoprotein: A Diagnostic Dilemma.
Cureus
November 2024
Pathology and Lab Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Hepatic mesenchymal hamartoma (HMH) is an uncommon, benign liver tumor predominantly affecting children under three years of age. It is characterized histologically by disorganized mesenchymal stroma, abnormal bile ducts, blood vessels, and hepatocytes. HMH can present as a large cystic mass, a solid mass, or a combination of both.
View Article and Find Full Text PDFVon-Meyenburg Complex: A Case of Elevated Gamma-GT.
Cureus
October 2024
Internal Medicine, Unidade Local de Saúde do Alto Minho, Viana do Castelo, PRT.
Article Synopsis
- The Von-Meyenburg complex, or biliary hamartomas, are benign growths of the bile ducts inside the liver, usually found by accident and often symptom-free.
- They can appear like cancerous lesions on imaging tests, but they typically have little importance regarding disease progression.
- There may be a genetic link in some families, particularly related to the PKHD1 gene, which is often associated with polycystic kidney and liver disease.
A case report and review of rheumatoid arthritis co-occurring with tuberous sclerosis complex, a rare occurrence.
Front Immunol
October 2024
Department of Rheumatology and Immunology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi, China.
Article Synopsis
- Rheumatoid arthritis (RA) is a common autoimmune disease, while tuberous sclerosis complex (TSC) is a rare genetic disorder.
- A 46-year-old woman presented with symptoms of polyarthritis and cough, initially suspected to be RA-ILD, but after further testing, multiple TSC-related conditions were identified.
- The patient was treated with everolimus alongside anti-rheumatic therapy, leading to an improvement in her cough symptoms.
Ductal hamartoma of the pancreas: A clinicopathologic study.
Hum Pathol
November 2024
Yale University School of Medicine, Department of Pathology, New Haven, CT, USA. Electronic address:
Article Synopsis
- Benign ductular proliferative lesions resembling hepatic von-Meyenburg Complexes have been identified in the pancreas, termed pancreatic ductal hamartomas (PDH), but their characteristics and causes are still unclear.
- A study reviewed three cases of PDH found during evaluations for other pancreatic conditions, often misdiagnosed as intra-ductal pancreatic mucinous cystic neoplasms, leading to surgical removal.
- PDH were found incidentally in 4.5% of pancreatic resections, showing varied sizes and histological features, but their connection to pancreatic cancer or IPMN remains uncertain.
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