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Conotoxin KM-RIIIJ reveals interplay between K1-channels and persistent sodium currents in proprioceptive DRG neurons.
Sci Rep
December 2024
School of Biological Sciences, University of Utah, Salt Lake City, Utah, USA.
Voltage-gated potassium channels (VGKCs) comprise the largest and most complex families of ion channels. Approximately 70 genes encode VGKC alpha subunits, which assemble into functional tetrameric channel complexes. These subunits can also combine to form heteromeric channels, significantly expanding the potential diversity of VGKCs.
View Article and Find Full Text PDFA label-free DNAzyme-Mediated biosensor for fluorescent detection of Lead (II) ion.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Lead ion (Pb) is a common environmental contaminant, extremely toxic, persistent, and easily adsorbed, concentrated, and enriched by agricultural products. Ingestion of this ion can result in health problems for humans, including neurological disorders, heart disease, brain damage, and mental deficiency. In this research, a sensitive fluorescent biosensing method for detecting Pb was developed using DNAzyme as the target recognition element and SYBR Green (SG) fluorescent dye as the signal indicator.
View Article and Find Full Text PDFThe Ability of AST-120 to Lower the Serum Indoxyl Sulfate Level Improves Renal Outcomes and the Lipid Profile in Diabetic and Nondiabetic Animal Models of Chronic Kidney Disease: A Meta-Analysis.
Toxins (Basel)
December 2024
Association pour L'utilisation du rein Artificiel en Région Parisienne (AURA), 75014 Paris, France.
The therapeutic benefit of the oral adsorbent drug AST-120 in chronic kidney disease (CKD) is related to an indoxyl sulfate (IS)-lowering action. Diabetes and dyslipidemia might worsen kidney damage in CKD. However, it is not known whether AST-120 influences lipid abnormalities as well as renal function in patients with CKD and diabetes.
View Article and Find Full Text PDFCharacterisation of High Alkaline-Tolerant Novel Ulvan Lyase from : Potential Applications of Enzyme Derived Oligo-Ulvan as Anti-Diabetic Agent.
Mar Drugs
December 2024
Jeju Bio Research Center, Korea Institute of Ocean Science and Technology (KIOST), Jeju-si 63349, Republic of Korea.
Green algae, particularly species, are rich in complex polysaccharides, such as ulvan, which have significant potential for biotechnological applications. However, the biochemical properties of ulvan depolymerised products remain underexplored. The enzymatic depolymerisation of ulvan has garnered attention owing to its cost advantages over alternative methods.
View Article and Find Full Text PDFCyanobacteria Boring Limestones in Freshwater Settings-Their Pioneering Role in Sculpturing Pebbles and Carbonate Dissolution.
Geobiology
December 2024
Department of Geography and Geology, Institute of Geological Sciences, Jagiellonian University, Kraków, Poland.
In freshwater lakes and rivers, cyanobacteria belonging to the family Leptolyngbyaceae bore > 1 mm deep into limestone pebbles by dissolving carbonate at the tip of their 3-8 μm-thick filaments. The abundance of these borings decreases downward while it is so high at the rock surface that micrometric debris is formed. Moreover, the disintegrated material on the pebbles' surface can be easily removed, for instance, when pebbles are grinding against each other due to wave or current action or when insect larvae settle and scratch loosened grains from the surface while constructing their cases.
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