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Ultrasound Predicts White Matter Integrity after Hypothermia Therapy in Neonatal Hypoxic-Ischemic Injury.
J Neuroimaging
November 2019
Neurosciences Intensive Care Nursery Group, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Hypoxic-ischemic injury (HII) is a major cause of neonatal death and neurodevelopmental disability. Head ultrasounds (HUS) in neonates with HII often show enhanced gray/white matter differentiation. We assessed the significance of this finding in predicting white matter structural integrity measured by diffusion tensor imaging (DTI) in neonates with HII.
View Article and Find Full Text PDFCerebral oxygen metabolism during and after therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: a feasibility study using magnetic resonance imaging.
Pediatr Radiol
February 2019
Department of Pediatrics (Neonatal-Perinatal Medicine), Department of Obstetrics and Gynecology, Penn State Health Children's Hospital, Hershey, PA, USA.
Background: Therapeutic hypothermia is the standard-of-care treatment for infants diagnosed with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). MRI for assessing brain injury is usually performed after hypothermia because of logistical challenges in bringing acutely sick infants receiving hypothermia from the neonatal intensive care unit (NICU) to the MRI suite. Perhaps examining and comparing early cerebral oxygen metabolism disturbances to those after rewarming will lead to a better understanding of the mechanisms of brain injury in HIE and the effects of therapeutic hypothermia.
View Article and Find Full Text PDFNeonatal neurobehavioral abnormalities and MRI brain injury in encephalopathic newborns treated with hypothermia.
Early Hum Dev
September 2013
Department of Psychiatry and Behavioral Sciences, Children's National Medical Center, Washington, DC, USA.
Background: Neonatal Encephalopathy (NE) is a prominent cause of infant mortality and neurodevelopmental disability. Hypothermia is an effective neuroprotective therapy for newborns with encephalopathy. Post-hypothermia functional-anatomical correlation between neonatal neurobehavioral abnormalities and brain injury findings on MRI in encephalopathic newborns has not been previously described.
View Article and Find Full Text PDFCost-effectiveness of therapeutic hypothermia after cardiac arrest.
Circ Cardiovasc Qual Outcomes
September 2009
Robert Wood Johnson Foundation Clinical Scholars program, the Center for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Therapeutic hypothermia can improve survival and neurological outcomes in cardiac arrest survivors, but its cost-effectiveness is uncertain. We sought to evaluate the cost-effectiveness of treating comatose cardiac arrest survivors with therapeutic hypothermia.
Methods And Results: A decision model was developed to capture costs and outcomes for patients with witnessed out-of-hospital ventricular fibrillation arrest who received conventional care or therapeutic hypothermia.
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