Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration.
J Exp Clin Cancer Res
January 2025
Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy.
Background: Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects that have been ascribed to the toxin in vitro.
View Article and Find Full Text PDFEndoscopic sleeve gastroplasty (ESG): indications and results-a systematic review.
Updates Surg
January 2025
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Obesity is a major global health problem and at the same time a financial burden for social security systems. For a long time, conventional lifestyle interventions have tried unsuccessfully to find a solution. It has been proven that only interventions that ultimately address the central control centers of hunger, appetite and satiety will lead to sustained weight loss.
View Article and Find Full Text PDFAtezolizumab plus bevacizumab as first-line treatment of unresectable hepatocellular carcinoma: interim analysis results from the phase IIIb AMETHISTA trial.
ESMO Open
January 2025
Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano (Milan), Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, (Milan), Italy. Electronic address:
Background: The treatment of advanced hepatocellular carcinoma (HCC) with atezolizumab and bevacizumab led to significant improvements in overall survival (OS), progression-free survival (PFS), and response rate compared with sorafenib in the phase III IMbrave150 trial. The etiology of background liver disease can differ between Eastern and Western populations, leading to a potentially different impact of systemic therapies; therefore the unequal representation must be considered in the IMbrave150 trial. To provide further data on the safety and effectiveness of atezolizumab and bevacizumab, the phase IIIb AMETHISTA (Atezolizumab plus bevacizumab in METastatic HCC Italian Safety TriAl) ran in a Western (Italian) population of patients with advanced HCC.
View Article and Find Full Text PDFSurgery time for stenosed Crohn's disease: Case report.
Int J Surg Case Rep
January 2025
Ministry of Heath-Jordan, Jordan.
Introduction And Importance: Stricture formation is a well-known Crohn's disease consequence that usually results from recurrent cycles of inflammation and healing and primarily affects the small intestine.
Case Presentation: In this report, we describe the case of a 35-year-old male with an 18-year history of Crohn's disease complicated by long-kinked ileal stricture who presented with a 3-month history of subacute small intestinal obstruction diagnosed with MR enterography and underwent failed medical treatment.
Clinical Discussion: The patient, a male showing signs of wasting due to a prolonged subacute small intestinal obstruction, underwent an MR enterography which revealed a 6-cm kinked ileal stricture.
Successful laparoscopic cytoreductive surgery for multiple (three) advanced recurrences of AGCT in a young woman. A case report.
Int J Surg Case Rep
January 2025
Department of Medical Sciences and Public Health, University of Cagliari, SS 554, km 4,500, 09042 Monserrato, Italy.
Introduction And Importance: Debulking surgery is the main approach for recurrent adult granulosa cell tumors (AGCTs), but the effectiveness of laparoscopic extensive cytoreduction in advanced cases and its impact on quality of life (QoL) remains unclear.
Case Presentation: A 34-year-old woman, who had a right adnexectomy for AGCT in 2020, was referred with an 8-month history of a large left ovarian cyst and amenorrhea. Preoperative evaluations indicated a recurrence 18 months post-diagnosis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!