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Nanoparticle containing recombinant excretory/secretory-24 protein of enhanced the cellular immune responses in mice.
Front Vet Sci
November 2024
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
poses a global challenge as a parasite affecting small ruminants, yet the problem of absence of an effective vaccine against infection still exists. This investigation sought to appraise the immunological reaction induced by recombinant excretory/secretory-24 (rHcES-24) in combination with complete Freund's adjuvant (CFA) and bio-polymeric nanoparticles (NPs) within a murine model. In this study, rHcES-24 was encapsulated in poly(d, l-lactide-co-glycolide) (PLGA) and chitosan (CS) NPs, administered subcutaneously to mice.
View Article and Find Full Text PDFExcretory-Secretory Products (-ES) Either Do Not Affect miRNA Expression Profile in THP-1 Macrophages or the Changes Are Undetectable by a Microarray Technique.
Pathogens
October 2024
Division of Parasitology and Parasitic Diseases, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-786 Warsaw, Poland.
is a liver fluke that resides in the bile ducts of various mammals. The parasitosis leads to economic losses in animal production estimated at USD 3.2 billion annually.
View Article and Find Full Text PDFHuman parasitic infections of the class Adenophorea: global epidemiology, pathogenesis, prevention and control.
Infect Dis Poverty
June 2024
Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570100, China.
Background: Human parasitic infections caused by Adenophorean nematodes encompass a range of diseases, including dioctophymiasis, trichuriasis, capillariasis, trichinellosis, and myositis. These infection can result in adverse impacts on human health and cause societal and economic concerns in tropical and subtropical regions.
Methods: This review conducted searches in PubMed, Embase and Google Scholar for relevant studies that published in established databases up to April 26, 2024.
The impact of microplastics polystyrene on the microscopic structure of mouse intestine, tight junction genes and gut microbiota.
PLoS One
June 2024
Department of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, China.
Microplastics, which are tiny plastic particles less than 5 mm in diameter, are widely present in the environment, have become a serious threat to aquatic life and human health, potentially causing ecosystem disorders and health problems. The present study aimed to investigate the effects of microplastics, specifically microplastics-polystyrene (MPs-PS), on the structural integrity, gene expression related to tight junctions, and gut microbiota in mice. A total of 24 Kunming mice aged 30 days were randomly assigned into four groups: control male (CM), control female (CF), PS-exposed male (PSM), and PS-exposed female (PSF)(n = 6).
View Article and Find Full Text PDFOpisthorchis viverrini excretory-secretory products suppress GLUT8 of cholangiocytes.
Parasitol Res
March 2024
Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Opisthorchis viverrini infection and the subsequent bile duct cancer it induces remains a significant public health problem in Southeast Asia. Opisthorchiasis has been reported to cause reduced plasma glucose levels among infected patients. The underlying mechanism for this phenomenon is unclear.
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