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From biofilms to biocatalysts: Innovations in plastic biodegradation for environmental sustainability.
J Environ Manage
February 2025
National Institute for Materials Advancement, Pittsburg State University, Pittsburg, KS, 66762, USA; Department of Chemistry, Pittsburg State University, Pittsburg, KS, 66762, USA. Electronic address:
The increase in plastic waste has evolved into a severe environmental crisis, which requires innovative recycling technologies to repurpose used plastic with adequate environmental protection. This review highlights the urgent need for innovative approaches to the treatment and degradation of post-use plastics. It investigates the promising role of biofilms in the biodegradation of polymers, especially for polymers such as polyethylene terephthalate (PET), polyurethane (PU), and polyethylene (PE).
View Article and Find Full Text PDFAkkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway.
Microb Biotechnol
January 2025
Huadong Medical Institute of Biotechniques, Nanjing, China.
Acetaminophen induced acute liver injury (ALI) has a high incidence and is a serious medical problem, but there is a lack of effective treatment. The enterohepatic axis is one of the targets of recent attention due to its important role in liver diseases. Disulfiram (DSF) is a multitarget drug that has been proven to play a role in a variety of liver diseases and can affect intestinal flora, but whether it can alleviate ALI is not clear.
View Article and Find Full Text PDFMyristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity.
Nat Commun
January 2025
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. Recent research has unveiled a surprising link between DNA damage response and energy metabolism. Here, we explore the role of Eepd1, a DNA repair enzyme, in regulating adipose tissue function and obesity onset.
View Article and Find Full Text PDFDevelopment of a Wine Yeast Strain Capable of Malolactic Fermentation and Reducing the Ethyl Carbamate Content in Wine.
Foods
December 2024
Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.
In winemaking, malolactic fermentation (MLF), which converts L-malic acid to L-lactic acid, is often applied after the alcoholic fermentation stage to improve the sensory properties of the wine and its microbiological stability. MLF is usually performed by lactic acid bacteria, which, however, are sensitive to the conditions of alcoholic fermentation. Therefore, the development of wine yeast strains capable of both alcoholic fermentation and MLF is an important task.
View Article and Find Full Text PDFRadiosynthesis and evaluation of novel F labeled PET ligands for imaging monoacylglycerol lipase.
Eur J Med Chem
January 2025
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, GA, 30322, United States. Electronic address:
Monoacylglycerol lipase (MAGL) is a 33 kDa cytosolic serine hydrolase that is widely distributed in the central nervous system and peripheral tissues. MAGL hydrolyzes monoacylglycerols into fatty acids and glycerol, playing a crucial role in endocannabinoid degradation. Inhibition of MAGL in the brain elevates levels of 2-arachidonoylglycerol and leads to decreased pro-inflammatory prostaglandin and thromboxane production.
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