AI Article Synopsis
- The study used radioimmunoassay (RIA) to detect IgM antibodies to Coxsackie B viruses (CBV) in patients with sarcoidosis and asbestos-related conditions.
- A significant percentage of patients with sarcoidosis (61%), benign asbestos pleural effusion, and diffuse asbestos-related issues (67%) tested positive for CBV-IgM antibodies, while healthy controls showed only 7% positivity.
- Patients with healed sarcoidosis or pleural plaques were negative for CBV-IgM, and testing for other antibodies like those to rubella and cytomegalovirus yielded no significant results, suggesting the CBV-IgM findings might be due to non-specific stimulation of B cells
Article Abstract
By using radioimmunoassay (RIA) for detection of IgM antibodies to Coxsackie B viruses (CBV), the occurrence of these antibodies was investigated in patients with sarcoidosis and asbestos-related lesions. Sixty-one per cent of the patients with sarcoidosis, all patients with benign asbestos pleural effusion, and 67% of those with diffuse asbestos-related pleural thickening showed CBV-IgM. Patients with healed sarcoidosis or pleural plaques were all negative, and among the "healthy" controls seven per cent had CBV-IgM. Thus, there was a high frequency of CBV-IgM in patients with sarcoidosis and in those with asbestos-related diseases. Since the titres could be the effect of an unspecific polyclonal stimulation of the B cells, sera were tested for antibodies to rubella and cytomegalovirus, but without any remarkable results.
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