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Effects of Potential Therapeutic Agents on Copper Accumulations in Gill of Crassostrea virginica.
In Vivo (Brooklyn)
January 2010
Department of Biology, Long Island University, Brooklyn, NY.
Copper is an essential trace element for organisms, but when in excess, copper's redox potential enhances oxyradical formation and increases cellular oxidative stress. Copper is a major pollutant in Jamaica Bay and other aquatic areas. Bivalves are filter feeders that accumulate heavy metals and other pollutants from their environment.
View Article and Find Full Text PDFMatrix metalloproteinase-1 is regulated in tuberculosis by a p38 MAPK-dependent, p-aminosalicylic acid-sensitive signaling cascade.
J Immunol
May 2009
Department of Infectious Diseases and Immunity, Imperial College London, Hammersmith Campus, London, United Kingdom.
Mycobacterium tuberculosis (M. tb) must cause lung disease to spread. Matrix metalloproteinases (MMPs) degrade the extracellular matrix and are implicated in tuberculosis-driven tissue destruction.
View Article and Find Full Text PDFActivity of twelve second-line antimicrobial agents against Mycobacterium tuberculosis in Taiwan.
J Chemother
April 2008
Department of Internal Medicine, Graduate Institute of Medicine Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Multidrug resistant (MDR) tuberculosis has emerged as a major public health problem worldwide. However, knowledge of the regional complete susceptibility to second-line drugs is rare, which impedes development of a global strategy of tuberculosis control. Presently, we determined the susceptibility of 125 isolates from southern Taiwan to 5 first-line and 12 second-line antituberculosis drugs.
View Article and Find Full Text PDFSensitive, selective detection and differentiation of salicylates and metabolites in urine by a simple HPTLC method.
J Anal Toxicol
January 1992
National Medical Services, Inc., Willow Grove, Pennsylvania 19090.
We present a method for salicylates which is slightly more labor intensive than the usual manual Trinder's test, but is much more sensitive and able to identify individual drugs or metabolites. A 2-mL acidified urine aliquot is briefly extracted with 5 mL ether, and the residue from evaporating the ether under nitrogen is chromatographed on a 250-microns silica gel HPTLC plate using benzene-acetic acid-diethylether-methanol (60:9:30:5) as mobile phase and 5% aqueous ferric chloride as chromogen. The hardiness of the method is evidenced by the Rf values, which vary by no more than 3% over a four-month period.
View Article and Find Full Text PDFIdentification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.
Drug Metab Dispos
September 1989
Department of Pharmacology, Morehouse School of Medicine, Atlanta, GA 30310-1495.
Recent studies from our laboratory have shown relatively high levels of polymorphic N-acetyltransferase (NAT)(EC 2.3.1.
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