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Pseudomonas aeruginosa Meningitis: A Case Report and Therapeutic Approach.
Cureus
December 2024
Emergency Department, Cheikh Khalifa International University Hospital, Mohammed VI International University Hospital, Casablanca, MAR.
We report the case of a 22-year-old mother with no medical history, admitted for gram-negative meningitis, identified as , 15 days after spinal anaesthesia. She was initially treated with dual antibiotic therapy, consisting of ceftazidime (2g three times a day) and amikacin. The first lumbar puncture (LP) performed 10 days approximately after the beginning of the treatment found no bacterial growth on the CSF culture.
View Article and Find Full Text PDFA three-way junction probe triggered CRISPR/Cas14a1 enhanced EXPonential amplification reaction for sensitive detection.
Anal Methods
January 2025
Xiang'an Hospital of Xiamen University, No. 2000, East Xiang'an Road, Xiang'an District, Xiamen City, Fujian Province, 361100, China.
(, PA) is a rod-shaped Gram-negative opportunistic bacterium capable of causing nosocomial infections during nursing, such as burn wound infections and meningitis. However, sensitive and rapid PA detection remains a huge challenge. Herein, a new fluorescent biosensor was developed for the sensitive detection of PA using a three-way junction (TWJ) probe for specific identification and CRISPR/Cas14a1 for enhanced exponential amplification.
View Article and Find Full Text PDFImpact of COVID-19 on the Prevalence and Drug Resistance of Bacteria Isolated From Bacterial Meningitis Cerebrospinal Fluid in Shandong Province: A Multicenter Retrospective Study.
J Med Virol
November 2024
Department of Clinical Microbiology, Children's Hospital affiliated to Shandong University, Jinan, Shandong, China.
Our objective was to evaluate the ramifications of the 2019 coronavirus disease (COVID-19) pandemic on the microbial profile and antimicrobial resistance patterns of bacteria isolated from cerebrospinal fluid (CSF) specimens of patients with bacterial meningitis. We conducted a retrospective analysis of laboratory results and clinical records about positive CSF cultures reported by the SPARSS network from 2017 to 2023. The study covered three distinct periods: January 2017 to December 2019 (before the COVID-19 pandemic), January 2020 to December 2022 (during the COVID-19 pandemic), and January 2023 to December 2023 (after the COVID-19 pandemic), with a total of 5793 CSF isolates collected.
View Article and Find Full Text PDFMetagenome mining divulges virulent and multidrug resistant ST242 and ST∗1b23 coinfecting an 8-month-old meningitis infant under ICU in Kampala, Uganda, East Africa.
Heliyon
October 2024
Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda.
Article Synopsis
- Pediatric meningitis poses a significant global health challenge, particularly in low-resource settings where the pathogens involved and their antibiotic resistance are poorly understood, prompting a study in Kampala, Uganda.
- The study used metagenome binning and antibiotic susceptibility testing to identify pathogens associated with infant meningitis, revealing two strains (ST242 and ST∗1b23) that showed considerable resistance to commonly used antibiotics, including ceftriaxone.
- Analysis of the virulence factors of these strains indicated mechanisms that target and disrupt the blood-brain barrier, suggesting that coinfection and interactions between these pathogens may complicate the treatment of meningitis and undermine the efficacy of ceftriaxone.
[Clinical profiles of community-acquired infections in children].
Zhonghua Er Ke Za Zhi
August 2024
Department of Infectious Diseases, Children's Hospital of Fudan University, ShangHai 201102, China.
To investigate clinical characteristics, outcomes and antimicrobial resistance of community-acquired (CAPA) infections in Chinese pediatric patients. This retrospective study was conducted at 6 tertiary hospitals in China during January 2016 to December 2018. The clinical and microbiological data of CAPA infected hospitalized children in Hainan and in other regions were collected and compared, and the antimicrobial resistance patterns, clinical characteristics and antibiotic therapy were analyzed.
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