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Stratified analyses refine association between TLR7 rare variants and severe COVID-19.
HGG Adv
October 2024
Institute of Human Genetics, University of Bonn School of Medicine and University Hospital Bonn, Bonn, Germany. Electronic address:
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.
View Article and Find Full Text PDFA Multidisciplinary Algorithm for the Evaluation of Acute Neurologic Deficits Improves Management of Cryptogenic Stroke or Transient Ischemic Attack.
Cureus
July 2023
Cardiology, Brooke Army Medical Center, Fort Sam Houston, USA.
The appropriate diagnosis and management of cryptogenic stroke and transient ischemic attack (TIA) is challenging and requires multidisciplinary involvement. Joint societal guidelines exist to guide the comprehensive evaluation of these entities. This study aimed to implement a standardized multidisciplinary diagnostic algorithm for cryptogenic stroke/TIA.
View Article and Find Full Text PDFAuthor Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Nature
July 2023
Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Nature
May 2023
Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Article Synopsis
- Researchers analyzed genetic data from 24,202 critically ill COVID-19 cases, showing that host genetics can help identify effective immunomodulatory therapies.
- They conducted a meta-analysis that revealed 49 significant genetic associations, including 16 new ones not previously reported.
- Key findings include potential drug targets related to inflammation, immune response, and viral entry, which could lead to new treatment strategies for severe COVID-19 cases.
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