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Glucagon like peptide-1 (GLP-1) agonists and cardiometabolic protection: historical development and future challenges.
Cardiovasc Diabetol
January 2025
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of cardiometabolic diseases, extending their therapeutic applications far beyond glycemic control in type 2 diabetes (T2D) and obesity. This editorial synthesizes key milestones, from the discovery of GLP-1 to recent clinical trials highlighting the pleiotropic effects of GLP-1RAs in addressing the interconnected spectrum of cardiometabolic conditions, with a focus on cardiovascular, renal, and hepatic benefits. In addition, as GLP-1RAs continue to reshape the management of cardiometabolic disease and global public health, we discuss future challenges to better elucidate their mechanisms of cardiometabolic protection and maximize their therapeutic potential.
View Article and Find Full Text PDFClinical performance of class II MOD fiber reinforced resin composite restorations: an 18-month randomized controlled clinical trial.
BMC Oral Health
January 2025
Conservative Dentistry Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Background: In recent years, there have been suggestions for new restorative strategies that aim to effectively utilize modern adhesive technologies and protect the remaining intact tooth structure. This study was conducted to evaluate the clinical performance of fiber reinforced resin composites in restoring Class II MOD cavities over 18 months.
Methods: Forty-five participants with class II MOD cavities were randomly enrolled.
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.
Nat Aging
January 2025
Translational Science and Therapeutics Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Somatic stem cell pools comprise diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In the bone marrow, myeloid-biased hematopoietic stem cells (myHSCs) are indispensable for replenishment of myeloid cells and platelets during inflammatory response but, at the same time, become irreversibly damaged during inflammation and aging. Here we identify an extrinsic factor, semaphorin 4A (Sema4A), which non-cell-autonomously confers myHSC resilience to inflammatory stress.
View Article and Find Full Text PDFGenetically-encoded targeted protein degradation technology to remove endogenous condensation-prone proteins and improve crop performance.
Nat Commun
January 2025
State Key Laboratory of Hybrid Rice, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei, China.
Effective modulation of gene expression in plants is achievable through tools like CRISPR and RNA interference, yet methods for directly modifying endogenous proteins remain lacking. Here, we identify the E3 ubiquitin ligase E3TCD1 and develope a Targeted Condensation-prone-protein Degradation (TCD) strategy. The X-E3TCD1 fusion protein acts as a genetically engineered degrader, selectively targeting endogenous proteins prone to condensation.
View Article and Find Full Text PDFSurface Copassivation Strategy for Developing Water-Soluble InP Colloidal Quantum Dots with High Luminescence and Suppressed Blinking.
J Am Chem Soc
January 2025
School of Physics and Optoelectronic Engineering, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Colloidal quantum dots (QDs) are promising emitters for biological applications because of their excellent fluorescence, convenient surface modification, and photostability. However, the toxic cadmium composition in the state-of-the-art QDs and their inferior properties in the aqueous phase greatly restrict further use. The performance of water-soluble indium phosphide (InP) QDs lags far behind those of Cd-containing counterparts due to the lack of effective surface protection.
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