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[The methods of diagnostic of immune thrombocytopenia of fetus and newborn].
Klin Lab Diagn
October 2016
The thrombocytopenia is found in 1%-5% of newborns. Depending on mechanisms of pathogenesis of thrombocytopenia is divided on immune and non-immune one. The reaction of of interaction between antibodies and antigens of superficial structures of cells are in the basis of immune destruction of thrombocytes.
View Article and Find Full Text PDFAutoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?
Acta Neuropathol Commun
December 2015
Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Immunological studies suggest that it is a T-cell mediated autoimmune disease, although an MS-specific target antigen for autoimmunity has so far not been identified. Models of experimental autoimmune encephalomyelitis in part reproduce features of MS, but none of the models so far covers the entire spectrum of pathology and immunology.
View Article and Find Full Text PDF[The superoxide theory of pathogenesis and therapy of immune disorders].
Vestn Ross Akad Med Nauk
July 2004
On the basis of the understanding that there are common development mechanisms for the inflammatory and immune reactions it was established that the activity of the oxidant-antioxidant system (OAS) correlates not only with a severity of the inflammatory reaction but also with a degree of immune disorders. Such disorders were studied in patients with endogenous uveitis and with cancer of the esophagus or uterine cervix, i.e.
View Article and Find Full Text PDFEvaluation of beta 1,4-galactosyltransferase in rheumatoid arthritis and its role in the glycosylation network associated with this disease.
Glycoconj J
June 1995
Division of Immunology, St George's Hospital Medical School, London, UK.
Evidence indicating an important link between glycosylation changes and autoimmune rheumatic disease is presented. Attention is especially focused on the interrelationship between reduced galactosylation of the oligosaccharides of IgG, auto-sensitization which is thought to be of central importance in the pathogenesis of rheumatoid arthritis (RA), and the enzyme beta 1,4-galactosyltransferase (GTase) that catalyses the addition of galactose to the oligosaccharide chains on this molecule. Data are presented to indicate that GTase undergoes a variety of normal and disease associated changes.
View Article and Find Full Text PDFBeta 1,4-galactosyltransferase variations in rheumatoid arthritis.
Adv Exp Med Biol
April 1996
Division of Immunology, St George's Hospital Medical School, London, United Kingdom.
Evidence indicating an important link between glycosylation changes and autoimmune rheumatic disease is presented. Attention is especially focused on the interrelationship between reduced galactosylation of the oligosaccharides of IgG, auto-sensitization to which is thought to be of central importance in the pathogenesis of rheumatoid arthritis (RA), and the enzyme beta 1,4-Galactosyltransferase (GTase) that catalyses the addition of galactose to the oligosaccharide chains on this molecule. Data are presented to indicate that GTase undergoes a variety of normal and disease associated changes.
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