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[Changes in HBs antigen and anti-HBs antibody in 77 patients with acute B-virus hepatitis].
Gastroenterol Clin Biol
February 1984
Serum HBs antigen (HBs Ag) and anti-HBs antibody (anti-HBs), as determined by radioimmuno-assay or ELISA methods, were studied in a group of 77 patients with acute icterogenic viral hepatitis over a period of at least three months and correlated to the evolution of the disease either to return to good health or to a chronic state. The cumulative rate of patients in whom HBs Ag had disappeared (n = 53) was a linear function of time during the first sixteen weeks. Correlation seemed even stronger in the subgroup of patients restored to good health before the third month.
View Article and Find Full Text PDFIn studies conducted in the early 1950s, sera from six asymptomatic blood donors, implicated in the transmission of viral hepatitis, were inoculated into 10 to 20 volunteers each. Five of these "implicated" donor sera transmitted clinically apparent hepatitis to the recipients. The stored serum samples from these studies have been reanalyzed using serologic markers for hepatitis B virus and hepatitis A virus infection.
View Article and Find Full Text PDFA collection of 1,985 lots of normal serum albumin (NSA) and 1,361 lots of plasma protein fraction (PPF) prepared between 1958 and 1974 were tested for the presence of hepatitis B surface antigen (HBsAg). Twenty-one percent of NSA lots and 71 per cent of PPF lots were HBsAg-positive by radioimmunoassay. There was considerable variation in frequency of HBsAg-positive lots among the 17 different manufacturers of NSA and the six manufacturers of PPF.
View Article and Find Full Text PDFThe AA. have determined the levels of argininesuccinatolyase (ASAL), sorbitoldehydrogenase (SDH) and guanase (GUA) in 65 cases of hepatitis of infancy, by comparison with the corresponding levels of transaminases. Of all the enzymes examined, transaminases were the most sensitive sign of liver damage, not only because of their more pronounced rise in the earlier stages of the disease, but also in consideration of their slower regression to normal values.
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