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Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment.
Pharmaceutics
November 2024
Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, Brazil.
Although androgenic alopecia is the most prevalent among non-cicatricial alopecia, it still lacks an effective and safe treatment. Dutasteride (DUT) shows promising results in hair regrowth; however, oral DUT intake causes serious sexual adverse events. Hence, we produced liposomes with different bilayer structures and evaluated the capability of such systems in increasing DUT accumulation in the hair follicles.
View Article and Find Full Text PDFThe Effect of Conditioned Medium from Angiopoietin-1 Gene-Modified Mesenchymal Stem Cells on Wound Healing in a Diabetic Mouse Model.
Bioengineering (Basel)
December 2024
Department of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Introduction: Mesenchymal stem cells (MSCs) have been introduced as a promising treatment for diabetic wounds. The effects of stem cell therapy are thought to be caused by bioactive molecules secreted by stem cells. Stem cell-based gene therapies can target bioactive molecules.
View Article and Find Full Text PDF10(E)-Pentadecenoic Acid Inhibits Melanogenesis Partly Through Suppressing the Intracellular MITF/Tyrosinase Axis.
Antioxidants (Basel)
December 2024
Department of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea.
Melanogenesis, the biological process responsible for melanin synthesis, plays a crucial role in determining skin and hair color, photoprotection, and serving as a biomarker in various diseases. While various factors regulate melanogenesis, the role of fatty acids in this process remains underexplored. This study investigated the anti-melanogenic properties of 10(E)-pentadecenoic acid (10E-PDA) through both in silico and in vitro analyses.
View Article and Find Full Text PDFEffects of Extract as a Feed Additive on Digestibility and Performance of Hair Lambs.
Animals (Basel)
December 2024
Faculty of Veterinary Medicine and Animal Science, Universidad del Tolima, Ibagué 730006, Tolima, Colombia.
Animal production requires efficiency, safety and environmental sustainability. Bioactive compounds from tropical plants could modulate ruminal fermentation, providing an alternative method to antibiotic treatment and addressing concerns about antibiotic resistance. In this study, the aim was to determine the effects of extract (TDE) on performance, intake, digestibility and blood parameters [i.
View Article and Find Full Text PDFHigh-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts.
J Vis Exp
December 2024
Division of Exercise Physiology, Department of Health Professions, West Virginia University School of Medicine; Cancer Institute, West Virginia University School of Medicine; 3Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine;
Article Synopsis
- Patient-derived xenografts (PDXs) offer a valuable approach to study breast cancer (BC) by mimicking real tumor environments and systemic effects, which in vitro models cannot achieve.
- A new method for orthotopic implantation of BC PDXs in immunodeficient mice eliminates the need for anesthesia, is less invasive, and allows for faster and scalable tumor model development.
- The validation process of the tumors includes assessing receptor status, confirming morphology, and verifying genetic similarity to patient samples, facilitating robust research across different BC subtypes.
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